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Experimental Study on Estrogenic Function of Triphasic Contraceptive Tablets

Yang Fangju, Zhang Min, Zhu Ling, Zhou Guanqiang, Zhou Suzhen, Fan Ailan. *Department of Pharmacology, West China of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China  
Objective To assess the estrogenic effect and activity of oral triphasic contraceptive tablets and provide the theoretical foundation for the use of homemade Kalirui in the treatment of metrorrhagic, menometrorrhagic, oligomenorrheic, and polymenorrheic dysfunctional uterine bleeding. Methods The vaginal smears of mice treated by triphasic contraceptive tablets (Kalirui and Trinordiol) were examined using light microscope. Radiational receptor analysis was made to measure the estrogenic effect of Kalirui and Trinordiol on rabbit uterus. Results Compared with the control group, the three dosage groups of homemade (Kalirui) triphasic contraceptive tablets and the import tablets (Trinordiol) group all showed obviously accelerate vagina kera epithelium forming ( P 0.01), especially in the first phase and second phase. Both Kalirui and Trinordiol were found to have higher affinity to estrogenic receptor, and there were no significant differences between them and the estrogenic standard sample( P 0.05). Conclusion Kalirui and Trinordiol triphasic oral contraceptive tablets have apparently estrogenic effect and activity.
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