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《Journal of Sichuan University (Medical Sciences Edition)》 2005-04
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A Clinical Study of Non-erosive Reflux Disease

LIU Yang, GONG Jun~△, DONG Lei, WANG Xue-qin, ZHU You-ling. Department of Gastroenterology, the Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China  
Objecitve To investigate the differences and similarities between non-erosive reflux disease(NERD) and reflux disease(RE). Methods This study covered 30 patients who were grouped by endoscopy into the cases of NERD (n=17) or RE (n=13). The two groups' symptom, mentality, and damage to life quality were compared. Biopsy was performed at 3 cm above LES in oesophagus. The patients were placed under ambulatory 24-h oesophageal pH and Bilitec2000 monitoring. And their responses to the same anti-reflux treatment were evaluated. Reults ① The proportion of female(58.82%) in NERD group was much higher than that(15.38%) in RE group (P0.05). ② There was no remarkable difference in symptom, damage to life quality between the NERD and RE groups (P0.05). But in respect to mentality, the NERD group had significantly higher anxiety and depression scores than did the RE group (P0.05). ③No noticeable difference in the pathological results of biopsy was seen between the NERD and RE groups (P0.05). ④ The NERD group had less abnormal reflux, compared with the RE group (P0.05). ⑤ The NERD group gave less response to treatment, compared to the RE group(P0.05). Conclusion NERD may be a kind of reflux disease different from RE.
【Fund】: 卫生部临床学科重点项目(No:2001230)资助
【CateGory Index】: R571
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