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《Journal of Sichuan University(Medical Science Edition)》 2007-01
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HIF-1α Expression and Relationship Involving Tumor Cell Proliferation and Angiogenesis in Human Breast Carcinoma

HAO Lang-song,WANG Geng,QIAN Kun,LUO Ting,LI Xiao-jun,WU Xiao-ting~△.Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China  
Objective To investigate the expression of hypoxia-inducible 1 alpha(HIF-1α) in human breast cancer and its relationship with vascular endothelial growth factor(VEGF) protein,proliferating cell nuclear antigen(PCNA) protein,other tumor biomarkers and clinical pathologic factors.Methods The immunohistochemical staining(SP) was used to measure the expression of HIF-1α,VEGF and PCNA in human breast fibroadenoma,usual hyperplasia and breast carcinoma.Results HIF-1α was not found expressing in breast fibroadenoma and hyperplastic lesions.In contrast,the positive rate of HIF-1α was found in the ductal carcinoma in situ 55%(DCIS,11/20) and the invasive breast carcinoma 85%(51/60).VEGF positivity in breast carcinoma was 81.3%(65/80).The total positive rate of PCNA in breast carcinoma was 75%(60/80),that in DCIS was 65%(13/20) and that in invasive carcinoma was 78.3%(47/60).Increased levels of HIF-1α were statistically significantly associated with increased expression of VEGF(r=0.762,P0.01) and PCNA(r=0.693,P0.01).Conclusion The upregulated expression of HIF-1α and VEGF in breast carcinoma has a close relationship with tumor angiogenesis,tumor cell proliferation,lymph node metastasis,ER status and stages of histology.This suggests that HIF-1α plays an important role in the carcinogenesis and progression of breast carcinoma;is wished to become a new target for radiotherapy,chemotherapy and biotherapy of tumor,which will offer the new ways to diagnosis and treatment of tumor.
【CateGory Index】: R737.9
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Chinese Journal Full-text Database 3 Hits
1 LI Yu-mei,CHEN Yong-qiang Department of Orthopedics and Traumatology,Shanghai Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,P.R.China;Hypoxia-inducible factor-1,a novel target for cancer cell apoptosis and angiogenesis[J];Chinese Journal of Cancer Prevention and Treatment;2008-12
2 ZHANG Jian-hai,WANG Jun-feng,TANG Xiao-yan,QIU Sheng-long(Department of General Surgery,The First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,China);Expression and significance of HIF-1α and CXCR4 protein in tissues of breast cancer[J];Journal of Shanghai Jiaotong University(Medical Science);2008-12
3 YANG Jie1,2,TIAN Lin1,CAO Shu-fen1,YANG Gui-fang2*(1Department of Gastroenterology,Renmin Hospital,Yunyang Medical college,Shiyan,Hubei 442000;2Department of Pathology,Zhongnan Hospital,Wuhan University,Wuhan,Hubei 430071,China);Expression and Clinical Significance of HIF-1α and VEGF in Colorectal Carcinomas[J];Journal of Yunyang Medical College;2008-02
Chinese Journal Full-text Database 10 Hits
1 GU Yi-xue,LI Han-xian,KAN Yin,WAN Han-qun,TANG Zhi-han,GAO Tian-shu.The Surgery Institute of Nanhua University,Hengyang 421001,China;Relationship of hypoxia inducible factor 1α and vascular endothelial growth factor expression with angiogenesis in gastric carcinoma[J];Journal of Chinese Physician;2006-03
2 SUN Wen-Zhou, YU Li-Bo, ZHANG Qing-Yuan Affiliated Tumor Hospital, Harbin Medical University, Harbin 150040, China;Expression and role of HIF-1α in carcinogenesis and progression of breast cancer[J];Journal of the Fourth Military Medical University;2007-02
3 FENG Hong-jie,CHEN Wei-liang,LI Jin-song,PAN Chao-bin.(Department of Oral Maxillofacial Surgery,Hangzhou First People's Hospital,Hangzhou 310006,China);Expression and significance of hypoxia inducible factor-1α in osseous sarcoma of jaws[J];Stomatology;2006-06
4 LI Fan1 YANG Weimin1 YE Zhangqun1(1Department of Urology,TongJi Hospital,TongJi Medical College,HuaZhong University of Science and Technology,Wuhan,430030,China);HIF-1α expression correlates with angiogenesis in bladder cancer[J];Journal of Clinical Urology;2007-04
5 HE Jian-bin, ZHANG Ping, OU Li-wen, WANG Xiao-hua Department of Respiration, First Affiliated Hospital of Nanhua University, Hengyang 421001, P.R.China;Expressions of HIF-1α and P-Selectin induced by Suramin combination with Quercetin in lung adenocarcinoma in mice[J];Chinese Journal of Cancer Prevention and Treatment;2006-11
6 LI XiaDepartment of Carcinoma,the Affiliated Hospital of Qinghai College,Xining 810001,P.R.China;Expressions and clinical significance of VEGF and HIF-1α in invasive cervical carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2007-11
7 ZHAO Duan-yi,QIAN Cong-kuan,JIANG Cong-qing,LIU Zhi-shu(The 2nd Department of Surgery,Hubei Provincial Corps Hospital of Chinese People's Armed Police Force,Wuhan 430061,China);Effects of HIF-1α on the apoptosis of colorectal cancinoma[J];Acta Academiae Medicinae CPAPF;2007-06
8 SUN Hong-cheng,QIU Zheng-jun,CAO Jun,LIU Chen,ZHANG Fang,HUANG Ke-jian.Department of General Surgery,Shanghai First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,China;HIF-1 alpha expression in pancreatic cancer tissue and its effect on cell apoptosis[J];Chinese Journal of Pancreatology;2007-02
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10 CHEN Ming-shui,YE Yun-bin,CHEN Qiang,et al(Fujian Provincial Tumor Hospital,Fuzhou 350014,China);Expression of chemokine receptor CXCR4 in breast cancer[J];Chinese Journal of Clinical Oncology and Rehabilitation;2005-06
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 DU Jing1,ZHAO Qiu21.Department of Gastroenterology,Zhejiang Provincial People's Hospital,Hangzhou 310014,P.R.China2.Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R.China;Inhibitory effect of YC-1 on stability and transcriptional activity of HIF-1 in hypoxic human liver cancer cells-HepG-2[J];Chinese Journal of Cancer Prevention and Treatment;2009-05
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