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《Journal of Sichuan University(Medical Science Edition)》 2007-01
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HIF-1α Expression and Relationship Involving Tumor Cell Proliferation and Angiogenesis in Human Breast Carcinoma

HAO Lang-song,WANG Geng,QIAN Kun,LUO Ting,LI Xiao-jun,WU Xiao-ting~△.Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041,China  
Objective To investigate the expression of hypoxia-inducible 1 alpha(HIF-1α) in human breast cancer and its relationship with vascular endothelial growth factor(VEGF) protein,proliferating cell nuclear antigen(PCNA) protein,other tumor biomarkers and clinical pathologic factors.Methods The immunohistochemical staining(SP) was used to measure the expression of HIF-1α,VEGF and PCNA in human breast fibroadenoma,usual hyperplasia and breast carcinoma.Results HIF-1α was not found expressing in breast fibroadenoma and hyperplastic lesions.In contrast,the positive rate of HIF-1α was found in the ductal carcinoma in situ 55%(DCIS,11/20) and the invasive breast carcinoma 85%(51/60).VEGF positivity in breast carcinoma was 81.3%(65/80).The total positive rate of PCNA in breast carcinoma was 75%(60/80),that in DCIS was 65%(13/20) and that in invasive carcinoma was 78.3%(47/60).Increased levels of HIF-1α were statistically significantly associated with increased expression of VEGF(r=0.762,P0.01) and PCNA(r=0.693,P0.01).Conclusion The upregulated expression of HIF-1α and VEGF in breast carcinoma has a close relationship with tumor angiogenesis,tumor cell proliferation,lymph node metastasis,ER status and stages of histology.This suggests that HIF-1α plays an important role in the carcinogenesis and progression of breast carcinoma;is wished to become a new target for radiotherapy,chemotherapy and biotherapy of tumor,which will offer the new ways to diagnosis and treatment of tumor.
【CateGory Index】: R737.9
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【References】
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1 GU Yi-xue,LI Han-xian,KAN Yin,WAN Han-qun,TANG Zhi-han,GAO Tian-shu.The Surgery Institute of Nanhua University,Hengyang 421001,China;Relationship of hypoxia inducible factor 1α and vascular endothelial growth factor expression with angiogenesis in gastric carcinoma[J];Journal of Chinese Physician;2006-03
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1 DU Jing1,ZHAO Qiu21.Department of Gastroenterology,Zhejiang Provincial People's Hospital,Hangzhou 310014,P.R.China2.Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,P.R.China;Inhibitory effect of YC-1 on stability and transcriptional activity of HIF-1 in hypoxic human liver cancer cells-HepG-2[J];Chinese Journal of Cancer Prevention and Treatment;2009-05
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