The Expression of CD 11a and CD 11b on Leucocytes in Cerebral Thrombosis *

Xiong Hai 1 Zhou Dong 2 Lei Song 3 He Xiaoyan 2 Luo Zuming 2 Chen Huaiqing 4 1. Department of Geriatrics, The Fourth Affiliated Hospital, (Chengdu 610041) ; 2. Department of Neurology, The First Affiliated Hospital; 3. Center of  

This study sought to understand the mechanism for the increased adhesion of leucocytes and endothelial cells in ischemic stroke. 20 patients with acute cerebral thrombosis and 20 healthy subjects as controls for expression of CD 11a and CD 11b (adhesion molecules on surface of leucocytes) were tested in vitro by flow cytometry (FCM) method. The results showed that compared with the control group, the patient group had significantly higher rates for expression of CD 11a on monocytes, granulocytes and lymphocytes ( P0.05 ). The CD 11b expression in the patient group was positively elevated on monocytes and granulocytes ( P0.05 ), but it was of lower positive rate on lymphocytes and no statistical difference was noted between the patient and control groups. These indicate that the expression of CD 11a and CD 11b on leucocytes increases in cerebral ischemic damage; thus adhesion of leucocytes and endothelial cells obviously increases. This change may aggravate post ischemic delayed neuronal death.

【Key Words】： Leucocyte CD 11a CD 11b Flow cytometry method Cerebral thrombosis
【Fund】： 国家自然科学基金
【CateGory Index】： R743.32

Download(CAJ format) Download(PDF format)

CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.