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《WEST CHINA JOURNAL OF PHARMACEUTCAL SCIENCES》 2000-04
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QUANTIFICATION OF INSULIN IN SUSTAINED RELEASE INSULIN NANOCAPSULES FOR INJECTION

YIN Zong ning,LU Bin ,WANG Guang jian School of Pharmacy,West China University of Medical Sciences,Chengdu 610041 China  
OBJECTIVE:To determine the contents of insulin in sustained release insulin nanocapsules for injection.METHODS: The method of first derivative UV spectrum was established and compared with HPLC assay.RESULTS:The supernatant and precipitate of insulin nanocapsules were separated by centrifuge and their recoveries of first derivative of UV spectrum were 100.31%±2.22%,100.66%±3.29%, and recoveries of HPLC were 97.96%±0.62%,96.34%±0.55%, respectively.CONCLUSION:The method of first derivative UV spectrum is quick and easy for contents determination of insulin in sustained release insulin nanocapsules for injection.
【Fund】: 高校博士点专项基金资助课题!批准号 950 4 13
【CateGory Index】: R927.2
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