Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《West China Journal of Pharmaceutcal Sciences》 2001-06
Add to Favorite Get Latest Update

PHARMACOLOGIC EFFECT OF RECOMBINANT BOVINE BASIC FIBROBLAST GROWTH FACTOR ON CRUSHED OPTIC NERVE IN RATS

LI Xiao kun 1,HU Ai lian 3,XU Hua 1,ZHENG Yuan yuan 3,YAO Cheng can 1,Hong An 2 1 Biopharmaceutical R&D Center of Jinan University,Guangzhou 510632,China; 2 Institute of Bioengineering of Jinan University,Guangzhou 510632,China; 3 Beijing  
OBJECTIVE:To study the effects of recombinant bovine basic fibroblast growth factor (bFGF)on repairing crushed optic nerves in rats. METHODS: Using calibrated cross action forceps a moderate crush injury was inflicted on the nerve. After crush injury, bFGF, saline and Vti B 12 was administered by using of retrobublar injection. After four weeks post injury their visual evoked potential response to flash (F VEP) was recorded. The apoptosis of RGCs was measured with flow cytometer. RESULTS: After 4 weeks of operation, the latent period extended and the swings were depressed. They have difference with normal F VEP. No response was observed in animals of treating with saline or VB 12 4 weeks later. The patterns of F VEP in bFGF treated animals was similar as normal. 800 U ?1 600 U and 2 400 U bFGF rescue the RGCs about 24.5%?27.3% and 28.5% respectively. 800 U ?1 600 U and 2 400 U bFGF prevent axon injury about 2.03?243 and 2.31 fold respectively. The flow cytometer showed that the rate of apoptosis was reduced markedly on 7 days at bFGF group. CONCLUSION: bFGF can significantly promote the functional repair of injury optic nerve.
【CateGory Index】: R774.6
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 Zhang Qingping,Huang Juen,Xie Chengxi,et al.(Department of Ophthalmology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021 China);PROTECTIVE ROLE OF BASIC FIBROBLAST GROWTH FACTOR AGAINST DEGENERATION AFTER OPTIC NERVE INJURY IN RABBIT EYES[J];Journal of Guangxi Medical University;2005-06
2 WU Jin-sheng, XIN Chang-tai, YANG Xiao-xia, XU Yuan, WEI Kan, AN Gui-lin, CAO Yang (Dpartment of Hand Surgury, The Affiliated Hospital of Shenyang Medical College, Shengyang 110024, China);Effects of bFGF complex degradation membrane on allograft of nerves[J];Journal of Regional Anatomy and Operative Surgery;2005-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 YUAN CHUN-YAN,NIU YONG-JUN,ZHANG RUI, et al(Department of Ophthalmology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);THE EXPRESSION OF WTp53,bax AND bcl-2 IN RETINA ISCHEMIA/REPERFUSION INJURY[J];Acta Academiae Medicinae Qingdao Universitatis;2006-04
2 JIANG Zhi Sheng 1, FU Min Gui 1, ZHAO Wen 2, WANG Xiao Hong 1, TANG Chao Shu 1 (1.Institute of Cardiovascular Disease, the First Hospital, Beijing Medical University, Beijing 100034, China; 2.Institute of Cardiovascular Research, Beijing M;Investigation of the antagonistic role of basic fibroblast growth factor on rat myocytes injury induced by hypoxia/reoxygenation[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;2000-02
3 HE Chun yan, XU Li jun, WANG Yi (Department of Ophthalmology,Southwest Hospital,Third Military Medical College,Chongqing 400038,China);Experimental study on expression of glial fibrillary acidic protein and effects of basic fibroblast growth factor on laser-injured retina[J];Journal of Traumatic Surgery;2003-01
4 ;Optic canal decompression through transcranial approach in treatment of traumatic optic nerve injury[J];Academic Journal of Second Military Medical University;2004-07
5 He Chunyan; Xu Lijun; Wang Yi; Qian Huanwen (Department of Ophthalmology, Southwest Hospital, Third Military Medical University, Chongqing,400038).;Study of the therapeutic effects of basic fibroblast growth factor on laserinduced apoptosis of retinal neurons in rabbits[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1999-06
6 DAI Chao, LIU Xiang (Department of Ophthalmology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China);Effects of EGF and bFGF on wound healing after penetrating keratic autoplasy in rabbits[J];Acta Academiae Medicine Militaris Tertiae;2001-02
7 SONG Lian- fang1,MENG Fan tang2,LIU Xi yu 2,et al. (1.Department of Technology,Super People′ s Court of Shandong Province,Jinan,250014; 2.Intermediate People′ s court of rizhao ,Shandong Province,rizhao 276800);A study of the relation between interval of the injury and the reaction of neurons, glial cells after experimental brain contusion[J];Journal of Forersic Medicine;2001-03
8 Jian-Guang Ding1 De-Yong Jiang21 Department of Ophthalmology, the Affiliated Hospital of Jining Medical College, Jining 272029, Shandong Province, China; 2 Department of Ophthalmology, the Second Xiangya Hospital of Central-South University, Changsha 410011, Hunan Province, China;Protection of retinal ischemia-reperfusion injury[J];International Journal of Ophthalmology;2005-05
9 Cheng Zhao,Zhi-Peng You Department of Ophthalmology,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China;Progression in the treatment of retinal ischemia-reperfusion injury[J];International Journal of Ophthalmology;2007-02
10 Zhang Qingping,Huang Juen,Xie Chengxi,et al.(Department of Ophthalmology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021 China);PROTECTIVE ROLE OF BASIC FIBROBLAST GROWTH FACTOR AGAINST DEGENERATION AFTER OPTIC NERVE INJURY IN RABBIT EYES[J];Journal of Guangxi Medical University;2005-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved