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《West China Journal of Pharmaceutcal Sciences》 2002-01
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EFFECTS OF POLYSACCHARIDE FROM ALOE VERA ON THE LPO OF SERUM AND HEPATIC IN ENDOTOXINIC AND NORMAL OLD RATS

WANG Li,BAO Xu,CEN Xiao bo,CAI Shao hui ,Hasegawa TakagakiSchool of Basic Medical Science and Forensic Medicine,Sichuan University,Chengdu 610041,China  
OBJECTIVE To evaluate the effects of polysaccharide extract (AP) from Aloe Vera on LPO( high level lipid peroxide) of serum and hepatic tissue.METHODS Animals were orally administered with different doses of AP for 30 days continuously; animal model of LPO was established by the treatment of 50 mg·g -1 LPS ip for 10 days continuously from the 21th day of the test. In addition, the control group was treated with NS. LPOconcentration of serum and hepatic tissue were measured to evaluate the preventive effect of anti oxidation of AP.RESULTS The results showed that AP at the doses of 10 mg·kg -1 and 50 mg·kg -1 could decrease the LPO concentration of serum and hepatic tissue in young endotoxinic and normal old rats obviously.CONCLUSION AP has an obvious effect of anti oxidation.
【Fund】: 国家重点科技攻关计划 (2 0 0 0 K0 1 0 5 0 5
【CateGory Index】: R285
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