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《West China Journal of Pharmaceutical Sciences》 2004-03
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Determination of ligustilide in Ligusticum chuanxiong Hort.by HPLC

CHAO Zhen-zhen 1,CHAO Ruo-bing * (West China School of Pharmacy,Sichuan University,Chengdu,610041,China)  
OBJECTIVE To establish an HPLC method to determine ligustilide from Ligusticum chuanxiong Hort.METHODS The column were Luna 5 μ silica(2)(150 mm×4.6 mm ID);the mobile phase consisted of n-hexane-ethyl acetate-chloroform(92∶3∶5);the flow rate was 0.8 ml·min -1 and the UV detector was set at 320 nm.RESULTS The method displayed good linearity within the concentration ranges of 0.1-2.0 μg(r=1.0000).The average recovery were 100.7%.The contents of three lots of crude drugs were 1.55%,1.33% and 1.70%,respectively.CONCLUSION This method is simple,accurate,replicate and suitable for the determination of ligustilide in Ligusticum chuanxiong Hort.
【CateGory Index】: R284
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