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《West China Journal of Pharmaceutical Sciences》 2005-04
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Effects of Borneol injection on experimental cerebral ischemia in mice

HE Xiao-jing~(1,2), ZHAO Li-mei~1, LIU Yu-lan~2 (1. The Second Affiliated Hospital of China Medical University, Shenyang 110004, China; 2.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016, China)  
OBJECTIVE To investigate the protective effects of Borneol infection against cerebral ischemia in mice and its mechanism. METHODS Mice models subjected to bilateral ligation of common carotid with vagus nerves, normobaric hypoxia and middle cerebral artery occlusion(MCAO) were used, to study the survival time of mice.The effect of Borneol on neurological deficit and the ratio of right/left cerebral hemisphere areas, infarct size in mice with middle cerebral artery occlusion. RESULTS Borneol could significantly prolong the survival time of mice. The score of neurological deficit,the ratio of right/left cerebral hemisphere areas and infarct size were significantly decreased as compared with control group. CONCLUSION Borneol may have a beneficial effect for the treatment of cerebral ischemic damage and its mechanism may be related to improvement of the energy metabolism.
【CateGory Index】: R285
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