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《West China Journal of Pharmaceutical Sciences》 2009-05
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Study on the renal toxicity of Caulis clematidis armandii in rats

PEI Jin,WAN De-guang,TANG Yuan,GUO Jin-lin,YANG Xin-jie,CAI Wen-long(Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan,610075 P.R.China)  
OBJECTIVE To investigate the renal toxicity of Caulis clematidis armandii in rats.The safety of four herbal drugs(Clematis armandii Franch.,C.montana Buch.-Ham.,C.argentilucida W.T.Wang,and C.peterae Hand.-Mazz.)was evaluated.METHODS Rats were randomly dividead into six groups and administrated with the former four herbal drugs(10 g·kg-1·d-1) and Caulis clematidis armandii(2 g·kg-1·d-1) by oral administration.During the experiment,the activites of rats were observed and the weight of rats were also measured.Then,the urine sample analysis,blood biochemical analysis and histopathological analysis were carried out.RESULTS Guan Mutong shows obvious renal toxicity.Compared to the results of control group and Guan Mutong group,the activities and weight of rats in other four groups were normal.CONCLUSION The results indicate that the four herbal drugs may be safe in clinical study.
【Fund】: 国家自然科学基金项目(批准号:30472149)
【CateGory Index】: R285
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