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《West China Journal of Pharmaceutical Sciences》 2013-05
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The anti-aging effect of total flavonoids from Chimonanthus praecox on aging mice induced by D-galactose

DUAN Ya-ping;LI Yuan;LI Shu-zhen;Guiyang College of Traditional Chinese Medicine;  
OBJECTIVE To investigate the anti-aging effect of total flavonoids from Chimonathus praecox(L.) Link(FCP) on aging mice induced by D-galactose.METHODS The aging mice model was established by injection of D-galactose for six weeks,then the mice were orally given FCP for three weeks.The spleen index,brain index,thymus index and the content of SOD,MDA in the blood,liver and brain tissue were measured.RESULTS Compared with blank group,the spleen index,brain index,thymus index and the content of SOD were significantly decreased but the MDA was significantly rose in model group.However,compared with model,the FCP could significantly raise the spleen index,brain index,thymus index and the content of SOD in the blood,brain and liver tissue,and decrease the level of MDA in the blood,brain and liver tissue.CONCLUSION The FCP exhibits significant anti-aging activity.The mechanism may be related to its enhancement of activity of scavenging free radicals and improving the immunity function.
【Fund】: 贵阳市科技计划项目(201120422号)
【CateGory Index】: R285.5
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