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《West China Journal of Pharmaceutical Sciences》 2015-04
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Determination of imperatorin and isoimperatorin in Tianma Toutong tablets by UPLC

HE Dan;YANG Lin;ZHANG Jing-qing;College of Pharmacy,Chongqing Medical University;Department of Pharmacy,Chongqing Medical and Pharmaceutical College;  
OBJECTIVE To establish an Ultra Performance Liquid Chromatography method for determination of imperatorin and isoimperatorin in Tianma Toutong tablets( TTT). METHODS Acquity UPLC BEH Cl8column( 50 mm × 2. 1 mm,1. 7 μm) was used,and the mobile phase was methanol and water by gradient elution mode with the column temperature of 30 ℃,a flow rate of 0. 3 m L·min- 1and detection wavelength of 248 nm. RESULTS The linear range of imperatorin was 1. 305- 26. 10 μg·m L- 1,the regression equation was Y = 1. 3448 × 104 X + 952( r = 0. 9999). The linear range of isoimperatorin was 0. 596- 11. 92 μg·m L- 1,and the regression equation was Y = 1. 0331 × 104 X + 588( r = 0. 9999). The average recovery was 98. 98%( RSD = 0. 87%) and 99. 07%( RSD =1. 09%),respectively. CONCLUSION The method is accurate,rapid and reliable,and can be used to determine imperatorin and isoimperatorin in TTT.
【CateGory Index】: R286.0;O657.72
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