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《WEST CHINA JOURNAL OF PHARMACEUTCAL SCIENCES》 1999-01
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INHIBITION OF PROLIFERATION OF HUMAN SMOOTH MUSCLE CELLS BY TANSHINONEⅡA

Du Junrong (School of Pharmacy, West China University of Medical Sciences Chengdu 610041)  
TanshinoneⅡA(Tan), a quinoid diterpenes, is an organic extract from Tanshen. the roots of salvia miltiorrhiza Bunge. This effective compound inhibits platelet aggregation and thrombosis, increases coronary blood flow, prevents myocardial ischemia. It is used to treat angina pectoris in clinics. In order to investigate the effect of Tan on smooth muscle cell, the cultured human smooth muscle cells (HSMC) were treated with different concentration of Tan. The cytotoxicity of Tan was analyzed by measuring mitchondrial dehydrogenase (MD) activity (MTT test), the anti proliferative effect by cell number counting and 3H thymidine incorporation into bFGF induced DNA synthesis in synchronized HSMC. The results indicated that a 6 day incubation with 15 μmol/L of Tan, the conce ntration which was not cytotoxic, had significant inhibition on the proliferation of HSMC ( P 0 01). IC 50 value for inhibition of bFGF induced DNA synthesis in synchronized HSMC was 2.8μmol/L. These results suggest that Tan might be also useful for the prevention of the proliferative vascular diseases.
【CateGory Index】: R285.6
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