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Influences of Different Abdominal Procedures on Postoperative Gastrointestinal Motility in Mice

WANG Zu yao,HU Ting ze,WEI Fu kang,et al. Department of Pediatric Surgery,First University Hospital,West China University of Medical Sciences,Chengdu 610041  
Obuective:To evaluate the influences of different abdominal procedures on postoperative gastrointestinal motility.Methods:Twenty-eight mice were randomly divided into 4 groups.Control group were only anesthetized,without any procedure applied;CO 2 group was introduced CO 2 intraabdominally(simulating laparoscopy);incision group was maed a 2cm mid abdominal incision;cecal group ,following opening the abdominal cavity,the cecum was gently manipulated for 3 minutes.two hours after operation,all animals were injected semi solid food into their stomachs and 13 hrs following feeding,the fecal pellets were harvested and allowed to dry for 2 hrs and weighed.Results:Fecal pellet output:Control group:1 20±0 12G;CO 2 group1 20±1 05g( P 0 05);incision group 0 72±0 11g( P 0 05);cecal group 0 24±0 02g( P 0 01).Conclusions Injecting CO 2 intraabdominally will not influence gastrointestinal motility,abdominal incision without intestinal manipulation could reduce gastrointestinal motility,however,the most serious factor to attenuate gastrointestinal motility is intestinal manipulation.
【CateGory Index】: R656
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