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《West China Medical Journal》 2008-06
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The Relationship between Smoking,Bone Turnover and Bone Mineral Density in Healthy Chinese Men

SUN Wen-li,LUO Xiang-hang,ZHOU Di-jun,et al.(1.Sections of Endocrinology,the Second Hospital of Yueyang,Yueyang 414000,China)  
Objective:To study the relationships of smoking and bone alkaline phosphatase(BAP),cross-linked N-telopeptides of type 1 collegen(sNTX)and bone mineral density in healthy men aged 20~80.Methods:BAP,sNTX were measured using ELISA,BMD at lumbar spine and hip was measured by dual energy x-ray densitometer,correlation of bone biochemical marker with age and BMD were fitted by ten kinds of regression models.Results:All subjectes were categorized into two groups according to whether smoking or not,there was a lower mean BMD of all sites and a higher BAP values in those smoking men(allP0.05).After adjusted age and BMI,smoking years was negatively correlated with BMD values at all sites.Smoking amount per day was negatively correlated with BMD values at anteroposterior lumbar spine and Ward's region while positively with the values(all P0.05).Conclusion:Smoking raises bone turnover rate and accelerates bone lose.In order to prevent osteoporosis,smoking should be inhibited.
【CateGory Index】: R580
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