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《West China Medical Journal》 2018-07
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Epigenetics and acute kidney injury

LIU Feng;TANG Jinhua;ZHUANG Shougang;Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine;  
Recent advances in epigenetics indicate that several epigenetic modifications, including acetylation,methylatio, and micro RNA(mi RNA), play an important role in the pathogenesis of acute kidney injury(AKI). Our study reveales that enhancement of protein acetylation by pharmacological inhibition of class I histone deacetylases leads to more severe tubular injury, and delays the restoration of renal structure and function. The changes in promoter DNA methylation occurs in the kidney with ischemia/reperfusion. Mi RNA expression is associated with the regulation of both renal injury and regeneration after AKI. Targeting the epigenetic process may provide a therapeutic treatment for patients with AKI. The purpose of this review is to summarize recent advances in epigenetic regulation of AKI and provide mechanistic insight into the role of acetylation, methylation, and mi RNA expression in the pathological processes of AKI.
【Fund】: 国家自然科学基金(81270778 81470920);; 国家自然科学青年基金(8140040669);; 科技部重大专项子课题基金资助(SQ2018YFA010257);; 上海市浦东新区科学和技术委员会科技发展基金(PKJ2017-Y19)
【CateGory Index】: R692
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