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《WEST CHINA MEDICAL JOURNAL》 1994-04
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Pre- and Postoperative Dynamic Study on the T Lymphocyte Subsets of the Peripheral Blood in Patients with Lung Cancer

Zhou Qinghua;Liu Jian;Liu Lunxu;Shi Yingkang;Zhao Yangfan;Jiang Guangliang;Yang Zhenhua (Department of Thoracocardiac Surgery, The First University Hospital.West China University of Medical Sciences, Chengdu)  
A serial changes of T lymphocyte subsets of the peripheral blood were detected by indirect immunofluorescent assay with mouse antihuman monoclonal antibody of OKT3,OKT4 and OKT8 in 58 patients with lung cancer before and after operation. In comparising theee tests with those of 24 casee of noncancerous thoracic lesions and 52 normal adults, the number of OKT3, OKT4 and OKT4/OKT 8 ratio from the cancer patients was significantly lower than that of the noncancerous thoracic lesions and normal individuals. On the contrary, the OKT8 cell from cancer patients was remarkably higher than that of the noncancerous thoracic lesions and normal adults. The degree of these changes was closely related to the stagcs of cancer and type of histological classification. The immunosuppression existing before operation became more severe within 1 week after the removal of the tumor and gradually recovered on the 14th postoperative day. It returned to normal level about 4 weeks postoporatively. These results suggested that patients with lung cancer had remarkable immunosuppression and impairement of cellinduced immunological function; and that surgical operatioh not only removed the tumor,but also broke the vicious circle of immunosuppression. Th erefore, the immune balance of patients might recovery after operation.
【CateGory Index】: R734.203
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【References】
Chinese Journal Full-text Database 1 Hits
1 LI Zhi-qiang,GAO Jian-qi,TAN Yao-ju,et al. (Department of Thoracic Surgery,Guangzhou Chest Hospital,Guangzhou,510095);The Pre-and Postoperative Variations of Th1/Th2 on the Cellular Immune Function in the Patients with Lung Cancer[J];中国误诊学杂志;2004-08
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 Liu Jie, Tian Zhigang, Sun Rui, et al. Shandong Cancer Biotherapy Center, Shandong Academy of Medical Sciences, Jinan 250062;The predominant expression of Th2 type cytokines in human tumor cells[J];中华肿瘤杂志;1998-02
2 Zhao Yongxiang;Zhou Hancha Department of Thoraric and cardiac Surgery,The Third Affiliated Hospital ,Hunan Medical University;CHANGES OF CELLULAR IMMUNE FUNCTION in PATIENTS WITH LUNG CANCER BEFORE AND AFTER OPERATION[J];湖南医科大学学报;1995-04
3 Zhou Qinghua;Liu Jian;Liu Lunxu;Shi Yingkang;Zhao Yangfan;Jiang Guangliang;Yang Zhenhua (Department of Thoracocardiac Surgery, The First University Hospital.West China University of Medical Sciences, Chengdu);Pre- and Postoperative Dynamic Study on the T Lymphocyte Subsets of the Peripheral Blood in Patients with Lung Cancer[J];华西医学;1994-04
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 Cao Zhe;He Ling;Zhou Jian;Zhang Yong;Mei Qi;Department of Oncology and Nuclear Medicine, Clinical Medicine College of Hubei College of Science and Technology;Cancer Center, Xianning Central Hospital, the First Affiliated Hospital of Hubei College of Science and Technology;Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology;;Changes of cellular immune function and cytokines secreted by T lymphocyte after chemotherapy in patients with advanced lung cancer[J];感染、炎症、修复;2017-02
2 ZHU Hai-bo,ZHAI Jin-fang.Shanxi Tumor Hospital,Taiyuan 030013,China;CD4~+ T cell cytokine level changes before and after chemotherapy[J];山西医药杂志;2006-10
3 ZHAO Yun-feng,CHEN Hong,LUO Yong-ai (Department of pulmonary,the First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016);Effects of Mycobacterium Vaccae Vaccine on Eosinophil Apoptosis and Expression of Fas Protein in Lung Tissues of Asthmatic Guinea Pig[J];中国误诊学杂志;2004-11
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