Pre- and Postoperative Dynamic Study on the T Lymphocyte Subsets of the Peripheral Blood in Patients with Lung Cancer

Zhou Qinghua;Liu Jian;Liu Lunxu;Shi Yingkang;Zhao Yangfan;Jiang Guangliang;Yang Zhenhua (Department of Thoracocardiac Surgery, The First University Hospital.West China University of Medical Sciences, Chengdu)  

A serial changes of T lymphocyte subsets of the peripheral blood were detected by indirect immunofluorescent assay with mouse antihuman monoclonal antibody of OKT3,OKT4 and OKT8 in 58 patients with lung cancer before and after operation. In comparising theee tests with those of 24 casee of noncancerous thoracic lesions and 52 normal adults, the number of OKT3, OKT4 and OKT4/OKT 8 ratio from the cancer patients was significantly lower than that of the noncancerous thoracic lesions and normal individuals. On the contrary, the OKT8 cell from cancer patients was remarkably higher than that of the noncancerous thoracic lesions and normal adults. The degree of these changes was closely related to the stagcs of cancer and type of histological classification. The immunosuppression existing before operation became more severe within 1 week after the removal of the tumor and gradually recovered on the 14th postoperative day. It returned to normal level about 4 weeks postoporatively. These results suggested that patients with lung cancer had remarkable immunosuppression and impairement of cellinduced immunological function; and that surgical operatioh not only removed the tumor,but also broke the vicious circle of immunosuppression. Th erefore, the immune balance of patients might recovery after operation.

【CateGory Index】： R734.203

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