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《Journal of Harbin Medical University》 1990-05
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Experimental Study on Myocardial Lesion Induced by Excessive Manganese in Rat

Zeng Xianhui et al (Institute of Keshan Disease)  
The manganese contents in artificial synthetic food were controlled. According to level of manganese contents, male wistar rats were randomly divided into two groups: normal manganese group and excessive manganese group. After eight weeks and twelve weeks of feeding, these rats were killed respectively and the hearts were removed immediately. The myocardial specimens were cxamined by light microscope, conventional and cytochemical electron microscope. The main findings were: focal coagulation necrosis of the cardial muscle can be Produced in rat with excessive manganese food. The lesion of the ectomenbranous system of the myocardial cell were observed. Activity of cytochemical reaction was decreased in cytochrome oxidasese and succinate dehydrogenase of mitochondria in excessive manganese group. These findings indicated that lesion of myocardial ectomembranous system, cytochrome oxidase and succinate dehydrogenase changes may play an important role in the pathogenesis of the myocardial lesion in excessive manganese rats.
【Key Words】： Manganese Lanthanum nitrate Succinate dehydrogenase Cytochrome oxidase
【Fund】： “七五”攻关课题之一
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