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《Journal of Harbin Medical University》 2001-06
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Expression and significance of heat shock protein 70 ,p53 protein and proliferating cell nuclear antigen in laryngeal cancer

YU Li min,SUN Ya nan,JIN De jun, et al (Department of Otolaryngology,The Second Affiliated Hospital, Harbin Medical University,Harbin 150086,China)  
Objective To determine the expression and significance of heat shock protein 70(Hsp70),p53 and proliferating cell nuclear antigen(PCNA) in laryngeal cancer.Methods The immunohistochemical staining SABC method was used.Results A higher level of the expression of Hsp70 was discovered in the more poorly differentiated cancer tissues than in the more well differentiated ones( P 0.01) .A close relation was observed in cancerous tissues between Hsp70 and p53( P 0.01), Hsp70 and PCNA labeling index ( P 0.001 ).The expression of Hsp70 had significant difference between with and without lymph node metastasis( P 0.05).Conclusion Hsp70 and p53 might have combined effect in the course of laryngeal cancer. Hsp70 plays an important role in the development of laryngeal cancer.
【Key Words】： Hsp70 p53 PCNA laryngeal cancer
【CateGory Index】： R739.65
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【References】
Chinese Journal Full-text Database 1 Hits
1 HAN Jin-xiang, GAO Xue-qin . Shandong Medicinal Biotechnological Center , Shandong Academy of Medical Sciences , Jinan 250062, China;Comments on the Molecular Biology of Cancer Research in China[J];Journal of Qilu Oncology;2003-01
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Xu Xianfa, Zhao Mei, Shi Yijing, et al. Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021;Expression of heat shock proteins in laryngeal carcinoma[J];CHINESE JOURNAL OF OTORHINOLARYNGOLOGY;1998-04
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Yu Limin, Guo Xiaofeng, Sun Yanan, Jin DejunFrom the Department of Otolaryngology\|Head and Neck Surgery, First Affiliated Hospital of Jilin University, Changchun 130021 (Dr. Yu Limin)];Expression and significance of heat shock proteins in laryngeal carcinoma[J];;2002-03
2 LIU Tao 1,TIAN Ling 2,WEI Yu-quan 2,ZHAO Ju-mei 2,LIANG Chuan-yu 1 (1.Department of Otorhinolargngology,West China Hospitol,Sichuan University,2.Center for Biotherapy of Tumor,West China Hospitol,Sichuan University. Key Laboratory of Biotherapy of Human Diseases,Ministry of Education,P.R.China.Chengdu,610041,China);Development in Study of Heat Shock Proteins and Tumor[J];West China Medical Journal;2004-03
3 Liu Huiling, Gao Yunhe, Wen Lichao △ (Department of Obstetrics and Gynecology, △Department of Pathology, the Second Affiliated Hospital of Lanzhou Medical College, Lanzhou 730030);Expression of HSPs in cervical squamous carcinomas[J];Chinese Journal of Clinical and Experimental Patholog;2002-05
4 LIU Hui-ling,WEI Fen (Department of Gynecology and Obstetrics,The People's Hospital of Gansu Province,Lanzhou,730000,China);Expression and clinical significance of HSP27 and P53 in cervical squamous carcinomas[J];Journal of Lanzhou University(Medical Sciences);2006-03
5 SU Hua,YANG Yan-jun,BO Ai-hua,et al.(Hebei North University,Hebei zhangjakou 075029,china.;The expression of HSP70 in transitional cell carcinoma of human bladder.[J];Journal of Modern Oncology;2004-04
6 CHENG Shu-bang,HONG Jian-qing,WANG Yuan-he. The Department of General Surgery,Second Affiliated Hospital(Chang Zhen Hospital),The Second Molitary Medical University,Shanghai,200003;Expression and Significance of Heat Shock Protein 70 and p53 Protein in Gastric Carcinoma[J];THE PRACTICAL JOURNAL OF CANCER;2000-03
7 Yang Yanjun, Zhang Jianglan, Bo Aihua,et al Zhangjiakou Medical college,Zhagjiakou 075000,China;The Study on Expression of HSP_(27) in Human Breast Carcinoma[J];Journal of Zhangjiakou Medical Collage;2004-01
8 Zhang Jianglan , Chen Xiuling, Bo Aihua,et al Zhangjiakou Medical College, Zhangjiakou, 075000,China;Expression and Significance of Heat Shock Protein 27 and 70 in Bladder Carcinoma[J];Journal of Zhangjiakou Medical Collage;2004-01
9 YIN Wan-zhong, ZHU Wei, PAN Yu-li, et al.(Dept of Otorhinolaryngolory Head and Neck Surgery, The First Clinical Hospital of Jilin University, Changchun 130021, China);Expression and significance of heat shock protein 70,p27 protein in parotid carcinoma[J];Chinese Journal of Laboratory Diagnosis;2005-06
10 LI Yepeng,HU Chengping,ZHANG Qing,HE Tiesheng,WU Ersheng(Department of Respiratory Medicine,Xiangya Hospital,Central South University,Changsha,Hunan 410008,P.R.China);Study of mechanism in growth inhibition of human lung adenocarcinoma with combined use of NS-398 and cisplatin[J];China Journal of Modern Medicine;2009-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WU Xiao-hua, XU Xiao-hu, SHEN Zhong-ying, et al. (Department of Forensic Pathology, Department of pathology, Shantou University Medical College, Shantou 515031, P. R. China);Expression of cell-cycle regulators cyclin D1 and CDK4 in esophageal squamous cell carcinoma[J];CHINESE JOURNAL OF CANCER;2000-01
2 ZHENG Jie, FANG Wei Gang, WU Bing Quan (Department of Pathology, Peking University School of Basical Sciences, Beijing 100083, China);Biological characteristics of metastatic cancer cells and cloning of human cancer metastasis-related genes[J];Journal of Beijing Medical University;2001-05
3 PU Yi ping,WU Jia lian,CAO Qian, et al (Department of ENT, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010);Influence of antisense oligodeoxynucleotide targeting against telomerase on expression of carcinoma gene of laryngeal carcinoma cells[J];Chongqing Medical Journal;2002-01
4 CHEN Ju Xiang 1, FAN Jing Ping 1, YING Kang 2, LIAO Jian Chun 1, LI Yao 2, TANG Rong 2, ZHOU Shui Miao 3, SUN Ai Hua 1, XIE YI 2, MAO Yu Min 2 (1. Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; 2. In;Study on differentially expressed genes in laryngeal squamous cell carcinoma by cDNA microarray[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;2000-09
5 LI Sheng,SHI Xue tao,ZHANG Xin,et al. Shandong Tumor Hospital,Jinan 250117;The relationship between Bcl-2,apoptosis and c-myc in pancreatic cancer[J];Journal of Hepatopancreatobiliary Surpery;2001-04
6 Lei Yiqun; Chen Ruhua; Yu Yanliang; Huang Shunsheng; Xiong Anling(Department of General Surgery, 414 Naval Hoopital Nanjing 210015);Expression of MTS1 Gene in Gastric Carcinoma and Precancerous Tissue[J];J0URNAL OF NANJING MILITARY MEDICAL COLLEGE;1998-04
7 FAN Bao?Xing,ZHANG Kai?Tai,MA Shu?Hua,XIE Ling,WANG Sheng?Qi,WU De?Chang (Institute of Radiation Medicine,Beijing 100850,P.R.China);Making lung cancer related cDNA microarray[J];Letters in Biotechnology;2001-01
8 PIN Ji-geng,YAN Chun-yin,CHEN Chi-lin,et al (Department of Urology, the Frist Hosptial Affilicated to Suzhou University, Suzhou 215006,China);The Expression of p16 and p53 Tumor Suppressor Gene in Bladder Carcinoma[J];Acta Academiae Medicinae Suzhou;2001-03
9 ZHU Chang jun, QU Xun, SONG Wen gang, MA Shi bin, DENG Wen(Dept. of Immunology, Taishan Medical College, Taian 271000,China);Construction of eukaryotic expression vector of tumor suppressor gene FHIT[J];Journal of Taishan Medical College;2001-03
10 WU Qiong, QIN Feng-zhan, ZHENG Rong-sheng, WANG Zi-an;Overexpression of MTA1 gene is associated with the invasion and metastasis of rectal carcinomas[J];Chinese Journal of Pathophysiology;2001-07
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