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《Journal of Harbin Medical University》 2004-03
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Study in the effect of a traditional Chinese drug Coixlipid on Hep-2 cell in vitro

XIAO Li feng,ZHANG Tian hong,LIU Jiang tao,et al(Department of Otorhinolaryngology,The First Clinical College,Harbin Medical University,Harbin 150001,China)  
Objective To study the inhibitory effects and mechanism of the traditional Chinese drug Coixlipid on laryngeal carcinoma cells Hep 2.Methods The inhibitory effect of Coixlipid on the growth of Hep 2 cell was evaluated by MTT assay.The single cell gel electrophoresis(SCGE) was used to detect the DNA damage of Hep 2 cells by Coixlipid.Results After Hep 2 cell had been treated with Coixlipid (5μl/ml~40μl/ml) for 48h,the growth of Hep 2 cell was significantly inhibited(P0.01).After the cell had been treated with Coixlipid (5μl/ml and 10μl/ml) for 48h,its DNA was damaged(P0.01).Conclusion The traditional Chinese drug Coixlipid can effectively inhibit the growth of Hep 2 cell in vitro,its mechanism is related to the DNA damage.
【CateGory Index】: R739.6
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