Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Harbin Medical University》 2005-06
Add to Favorite Get Latest Update

Establishment and evaluation of experimental animal model of CFA induced adjuvant arthritis in rats

CHEN Bai-song,XU Yu-dong,ZHONG Shu-qi,et al(Department of Anatomy,Harbin Medical University,Harbin 150086,China)  
Objective To establish adjuvant arthritis(AA) models in rats induced by CFA and take a comprehensive evaluation.Methods We injected CFA to the left foot of rats.The articular swelling degree was scored,the enzyme-linked immunoabsorbent assay(ELISA) was used to detect the contents of the Collage Ⅱantibody in serum,the transmission electron microscope(TEM) was used to observe the ultramicrostructure of lymphoid node in fossa poplitea and synovium in joint.Results The level of the CⅡantibody in serum of model group was remarkably increased after CFA injected,and it was confirmed typical pathological changes of RA by TEM.Conclusion The AA model is successfully built in rats induced by CFA.It provides more satisfactory material for the study of the pathogenesis and therapeutic effect of drugs.
【Fund】: 哈尔滨市留学归国科研基金课题(2003AFLXJ011)
【CateGory Index】: R-332
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 6 Hits
1 FENG Han-Chao,XU Yu-Dong,XU Hai,et al(The Hospital of Heilongjiang Province,Harbin 150036,China);Effects of IFN-γ by oral administration of type Ⅱ collagen on adjuvant arthritis in rats[J];Heilongjiang Medical Journal;2006-03
2 ZHANG Wen-tao TANG Lu-hong CHEN Wei CHEN Dong-qun DENG Chao (School of Medicine and Pharmaceutics,Jiangnan University,Wuxi 214122,China);Therapeutic effect of collagen from Cyanea nozakii on adjuvant arthritis in rats[J];Chinese Journal of Marine Drugs;2008-04
3 GU Qiang-rong1,WANG Li-ming1,XU Yan1,LI Shao-hua2,MENG Qing-le2,YAO Qing-qiang1,YANG Jian-ping1,GUI Jian-chao1(1.Department of Orthopaedics;2.Department of Nuclear Medicine,the First Hospital of Nanjing Affiliated of Nanjing Medical University,Nanjing 210006,Jiangsu,China);Technetium-99 conjugated with methylene diphosphonate:An effective agent for adjuvant arthritis in rats[J];Journal of Medical Postgraduates;2008-02
4 Gu QR,Wang LM,Xu Y,Li SH,Meng QL,Yao QQ,Yang JP,Gui JC 1Department of Orthopaedics,2Department of Nuclear Medicine,Nanjing First Hospital Affiliated to Nanjing Medical University,Nanjing 210006,Jiangsu Province,China;Colloidal chromic phosphate ~(32)P via intraarticular injection improves correlated indexes of rats with adjuvant arthritis[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-09
5 CHEN Rui,LIN Da-yong,FU Yong-qiang,advisor:GUAN Qing-zeng,GU Song(Liaoning University of TCM,Shenyang 110032,Liaoning,China);Immunoregulatory Effects of PGAD on Rheumatoid Arthritis rats[J];Chinese Archives of Traditional Chinese Medicine;2008-05
6 ZHANG Hui~1,ZHANG Chong~1,NIU Bing-xuan~1,NIE Hong~2,LIU Ju-yuan~1 (1.Department of Pharmacology,Xinxiang Medical College,Xinxiang 453003,China;2.Department of Pharmacology,Jinan University,Guangzhou 510632,China );Effects of coumarins from Radix Angelicae Dahurica on 5-hydroxytryptamine,5-OH-indoleacetic acid and dopamine contents in brain tissue of mice with inflammatory pain[J];Journal of Xinxiang Medical College;2010-01
Chinese Journal Full-text Database 10 Hits
1 TANG Zhao liang,SONG Xiao ge,ZHANG Fu qing,CHEN Quan zhu, HOU Zheng ming,ZHANG Dao qing,YUAN Jing (Institute of Acupuncture and Moxibustion,Anhui College of TCM,Anhui Hefei 230038,China);ANTIINFLAMMATORY AND REPERCUSSIVE EFFECT OF MOXIBUSTION AND ITS INFLUENCE ON CYTOKINES,FREE RADICALS IN ARTHRITIC RATS[J];Journal of Anhui Traditional Chinese Medical College;2001-05
2 LIU Jian,HAN Ming xiang,ZHANG Wan dong,CHEN Guang liang,LEI Li (The First Hospital Affiliated to Anhui College of Traditional Chinese Medicine,Anhui Hefei 230031,China);INFLUENCE OF XINFENG CAPSULE ON SERUM LEVEL OF IL-1, TNFα,IL-4,AND IL-10 IN ADJUVANT ARTHRITIS RATS[J];Journal of Anhui Traditional Chinese Medical College;2002-02
3 TANG Zhao liang, SONG Xiao ge , ZHANG Fu qing,HOU Zheng ming, CHEN Quan zhu, LIU Xian hua(Institute of Acupuncture and Moxibustion,Anhui College of Traditional ChineseMedicine, Anhui Hefei 230038, China);Experimental Study on Anti-inflammatory andImmunological Mechanism of Moxibustion[J];Journal of Anhui Traditional Chinese Medical College;2003-02
4 SUN Wei1,PAN Feng1,TANG Min-ke2,ZHANG Qian2,ZHANG Zheng-zhi1(1.Department of Centre Laboratory,Faculty of High Altitude Medicine,Third Military Medical University,Chongqing 400038;2.Department of Cardiololgy,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Effect of Taurine on Intracellular Free Calcium Concentration of Cultured Myocardial Cells of Neonatal Rat[J];Amino Acids & Biotic Resources;2007-03
5 LIU Huiling, WANG Dong, ZAHNG Jingang. Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850;The Progress of Collagen in Clinical Medicine[J];Beijing Biomedical Engineering;2005-03
6 SUN Yun-ting,WEI Ming,JIANG Xue-lian,LIU Zhi-xue,YANG Ji-chao(Department of TCM,Affiliated Hospital of Binzhou Medical University,Binzhou 256603,China);Clinical study of rheumatoid arthritis with midnight-noon ebb-flow acupoint selection[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-02
8 CHEN Sheng-jun,ZENG Ming-yong,DONG Shi-yuan ( Fishery College, Ocean University of China,Qingdao 266003,China);Progress in the Study of Collagen and Active Peptide of Fisheries[J];Fisheries Science;2004-06
9 LIU Yi, QIAN He (School of Food Science and Technology, Southern Yangzte Univeristy, Wuxi214036,China);A Review: Structure of Glycosaminoglycan[J];Fisheries Science;2005-05
10 GUO Yao,ZENG Ming-yong,CUI Wen-xuan(Food Engineering Department,Fishery College,Ocean University of China,Qingdao 266003,China);Aquatic Collagen and Active polyeptide[J];Fisheries Science;2006-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 GU Qiang-rong,WANG Li-ming,GUI Jian-chao,SONG Hua-rong,HUANG He(Department of Orthopedics,The First Hospital of Nanjing,Nanjing Medical University,Nanjing 210006,Jiangsu,China);Arthroscopic synovectomy for diffused pigmented villonodular synovitis of the knee[J];Journal of Medical Postgraduates;2009-08
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved