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《Journal of Harbin Medical University》 2005-06
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Establishment and evaluation of experimental animal model of CFA induced adjuvant arthritis in rats

CHEN Bai-song,XU Yu-dong,ZHONG Shu-qi,et al(Department of Anatomy,Harbin Medical University,Harbin 150086,China)  
Objective To establish adjuvant arthritis(AA) models in rats induced by CFA and take a comprehensive evaluation.Methods We injected CFA to the left foot of rats.The articular swelling degree was scored,the enzyme-linked immunoabsorbent assay(ELISA) was used to detect the contents of the Collage Ⅱantibody in serum,the transmission electron microscope(TEM) was used to observe the ultramicrostructure of lymphoid node in fossa poplitea and synovium in joint.Results The level of the CⅡantibody in serum of model group was remarkably increased after CFA injected,and it was confirmed typical pathological changes of RA by TEM.Conclusion The AA model is successfully built in rats induced by CFA.It provides more satisfactory material for the study of the pathogenesis and therapeutic effect of drugs.
【Fund】: 哈尔滨市留学归国科研基金课题(2003AFLXJ011)
【CateGory Index】: R-332
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