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《Journal of Harbin Medical University》 2007-04
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The correlation between the expressions of gastrin,somatostatin and the metastasis of lymph node in gastrointestinal carcinoid

ZHANG Shu-jie,WANG Rui-fen,WANG Zheng-cai,et al (Department of Pathology,The First Clinical College,Harbin Medical University,Harbin 150001,China)  
Objective To investigate the expressions of 5-HT,glucagon,somatostatin and gastrin in gastrointestinal carcinoid and its clinical significance.Methods Immunohistochemistry SP method was used to examine the expressions of the four hormonal proteins in 36 cases of gastrointestinal carcinoid.Results The positive rates of the gastrin increased in the poor differentiated gastrointestinal carcinoid tissues(P0.05).The expression of gastrin was related to the metastasis of lymph node in gastrointestinal carcinoid tissues(P0.05).The expression of the somatostatin was associated with the stage of tumor,the positive rates of somatostatin decreased in the lymph node metastasis of gastrointestinal carcinoid(P0.01).5-HT and glucagon had no correlation with the differentiation and lymph node metastasis of carcinoid(P0.05).Conclusion When gastrin and somatostatin combine with the membrane receptor of cell,they can stimulate or inhibit the proliferation of the tumor cells.These data indicate that the hormonal proteins may be valuable markers to predict the biologic behavior and prognosis in gastrointestinal carcinoid.
【Fund】: 黑龙江省教育厅科学技术研究项目(10551205);; 黑龙江省科学技术攻关项目(GB06C40203)
【CateGory Index】: R735
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【References】
Chinese Journal Full-text Database 2 Hits
1 ZHAO Ying,TIAN Ya-ting,JIANG Ya-nan,WU Li-min,BO Ai-hua.(Hebei North University,ZhangJiaKou 075029);The observation of endocrine cell in fetus′ gastric mucosa.[J];Chinese Journal of Birth Health & Heredity;2008-07
2 LIU Jun1,ZHOU Jian-jiang1,2,ZHAO Yan1,XIE Yuan1(1Key Laboratory of Molecular Biology,2 Clinical Laboratory of Affiliated Hospital,Guiyang Medical College,Guiyang 550004,China);Gastrin promotes the migration and invasion of gastric cancer cells[J];Chinese Journal of Pathophysiology;2013-04
【Citations】
Chinese Journal Full-text Database 1 Hits
1 LIN Yan,WANG Xian-Yan,ZHANG Jing-Yan,et al(Department of Pathology,Qiqihaer Medical College,Qiqihaer 161042,China);Significance of somatostatin and p21~(WAF1/CIP1) protein expression in gastrointestinal carcinoid[J];Chinese Journal of Clinical Oncology and Rehabilitation;2006-03
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 ZHAO Ying,TIAN Ya-ting,JIANG Ya-nan,WU Li-min,BO Ai-hua.(Hebei North University,ZhangJiaKou 075029);The observation of endocrine cell in fetus′ gastric mucosa.[J];Chinese Journal of Birth Health & Heredity;2008-07
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 Lin Jing;Bo Aaihua;Yao Xixian;et al.(Zhangjiakou Medical collage,075000.HeBei Medical university 050017).;Study on Relationship of Gastrin. Somatostatin 5-Hydroxytryptamine and Pathologic Change in Chronic Atrophic Gastritis[J];CHINESE JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY;1996-04
2 SUN Wei-hao1, CAO Da-zhong2, YU Qian2, OU Xi-long2, SHEN Hong 3, YU Ting2, ZHU Feng2, SUN Yun-liang2, FU Xi-ling2(1Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 21009, China;Department of Gastroenterolog y, Zhongda Hospital, Southeast University, Nanjing 210009, China;Depart ment of Gastroenterology, Jiangsu Prov incial Hospital of Traditional Chinese Medicine, Nanjing 210029, China);Effects of gastrin on expression of cyclooxygenase and growth factors in rat gastric mucosa[J];Chinese Journal of Pathophysiology;2005-02
3 SHI Xiao-yu1,TAO Si-feng2,CHEN Li1,PENG Shu-you1,HOANG-VU Cuong3 (1Department of General Surgery,2Department of Oncosurgery,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China.3Department of Surgery,Martin Luther University of Halle-Wittenberg,Halle 06099,Germany.);Effect of CD97 gene silencing by small interfering RNA on migration and invasion of gastric carcinoma cell lines[J];Chinese Journal of Pathophysiology;2011-07
4 LIN Yan,WANG Xian-Yan,ZHANG Jing-Yan,et al(Department of Pathology,Qiqihaer Medical College,Qiqihaer 161042,China);Significance of somatostatin and p21~(WAF1/CIP1) protein expression in gastrointestinal carcinoid[J];Chinese Journal of Clinical Oncology and Rehabilitation;2006-03
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