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《Journal of Harbin Medical University》 2008-03
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Expression and clinical significance of matrix metalloproteinase 9 and survivin in gestational trophoblastic disease

MENG Hai-yun,LI Fu-qin,ZHAO Lin-lin,et al(Department of Gynecology,The Second Clinical College,Harbin Medical University,Harbin 150081,China)  
Objective To investigate the expressions of matrix metalloproteinase 9(MMP9) and survivin in human gestational trophblasts and evaluate their correlation with the gestational trophoblastic disease.Methods Immunohistochemical strep-tavidin-peroxidase(S-P) method was used to detect the expressions of MMP9,survivin in normal human cytotrophoblast cells(12w),hydatidiform moles,invasive moles,and choriocarcinoma.Results ①MMP9,survivin expressions were detected in all types of trophoblastic cells,the staining was markedly increased with the development of the malignant transformation(P0.05);②There was a positive correlation between the two(P0.05).Conclusion MMP9,survivin are involved in the invasion of the normal human cytotrophoblast cells.Two factors may cause the invasion and metastasis.Furthermore,they may be used as indicators of the stage of gestational trophoblastic disease development and to assess the prognosis and clinical therapy.
【CateGory Index】: R737.33;R714.2
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1 Bu Yanggao,Zhang Hongfu,Hu Yong,et al The Department of Obstetrics and Gynecology 105th Hostpital PLA,Hefei 230031;Matrix metalloproteinases and it's tissue inhibitors in gestational trophoblastic[J];Anhui Medical Journal;2009-04
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