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《Journal of Harbin Medical University》 2009-01
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Regulation role of Shikonin in late stages of murine collagen-induced arthritis

DAI Qiao-mei,WANG Jin-feng,ZHANG Feng-shan(Department of Rheumatolgy,The Second Clinical College,Harbin Medical University,Harbin 150081,China)  
Objective To investigate the antiinflammatory or immunomodulatory effect of exogenous shikonin on established murine collagen-induced arthritis(CIA).Methods Mouse were injected intraperitoneally with shikonin(5 mg/kg) for 10 days along after the onset of CIA.The arthritis response was monitored visually by macroscopic scoring.Reverse transcription-polymerase chain reaction(RT-PCR) was used to determine the mRNA expression of cytokine in patella with adjacent synovium in CIA mouse.Histology of knee was used to assess the occurrence of cartilage destruction and bone erosion.Results A pronounced amelioration on macroscopic score and cartilage destruction was found in mouse treated with shikonin on established CIA.Moreover,the mRNA levels of Th1 cytokines(TNF-α and IL-12) was significantly inhibited both in the synovial tissue and in the articular cartilage in treated groups compared with those in control groups,and the mRNA levels of IL-6 was down-regulated in mice with established CIA after treatment with shikonin.Conclusion A pronounced amelioration on macroscopic score and histology is found in mouse treated with shikonin on established CIA,which proves shikonin exert its anti-inflammatory effects through the inhibition of Th1 cytokines.
【Fund】: 哈尔滨医科大学博士课题基金;; 黑龙江中医药大学科研课题(200721)
【CateGory Index】: R285.5
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