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《Marine Sciences》 1991-05
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INHIBITIVE EFFECT AND MECHANISM OF POLYSACCHARIDE OF SPIRULINA PLATENSIS ON TRANSPLANTED TUMOR CELLS IN MICE

Liu Lisheng, Guo Baojiang, Ruan Jihong, Qin Guangquan and Wu Botang(Insititute of Oceanology, Academia Sinica, Qingdao, 266071)(Biotech, Dept., Zhongkai Agrotechnical College, Guangzhou, 510225)(South China Sea Institute of Oceanology, Academia Sinica, Guangzhou, 510301)  
Polysaccharide of Spirulina platensis can inhibit the proliferation of ascitic hepatoma cells of mice in the concentration of 200 mg/kg. It can inhibit the incorporation of 3H-thymidine, 3H-uridine and 3H-leucine into DNA, RNA and protein synthesis of sarcoma 180 and ascitic hepatoma cells during the period of 24 h after exposure in vetro. The degree of inhibition increases with the extending of incubation time. Polysaccharide of Spirulina pla-tensis can inhibit DNA synthesis of sarcoma 180 and ascitic hepatoma cells. The mechanism of inhibition belongs to DNA metabolism disturbance.
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