Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Marine Drugs》 1998-03
Add to Favorite Get Latest Update

STUDIES ON THE CHEMICAL COMPOSITION AND AN-TITUMOR ACTIVITY OF THE GLYCOPROTEIN FROM CHLAMYS (AZUMAPECTEN)FARRERI

Gu Qianqun,Fang Yuchun,Wang Changyun et al (Marine Drugs and Foods Institute,Ocean University of Qingdao,Qingdao 266003)  
Glycoprotein of Chlamys ( Azumapecten ) farreril ( GCFI) was prepared from the skirt of scallop Chlamys (Azumapecten)farreri by extraction with hot water,isolation and purification with column chromatography "on DEAE-cellulose and Sephadex G-100 successively. GCFI was hydrolyzes with enzymes to obtain glycoprotein of Chlamys (Azumapecten)farreri IKGCFID-The chemical composition and antitumor activity of GCFI and GCFII were studied. The result showed that GCFI and GCFII were two glycoproteins in which the composition and content of protein and sugar were different. They could obviously inhibit Sarcoma 180 cells proliferation of mice with the inhibition rate of 47. 29% and 46. 97%,respectively. Pharmacological test indicated that antitumor activity of GCFI and GCFII were associated with the structure of sugar in the molecules.
【Fund】: 山东省科委资助项目(专项合同号 95-48)
【CateGory Index】: R284.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved