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《CHINESE JOURNAL OF MARINE DRUGS》 1999-01
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THE STUDY ABOUT IL-2 ACTIVITY INDUCED BY SEPIA IN MICE

He Shen; Xie Guanglin;Liu Fengzhi;, Lu Changlong. (Department of Immunology,China Medical University,Shenyang 110001 )  
To study the inducing effect of sepia on the IL-2 level of mice. Method:Giving sepia to BALB/c mice for continuous 5 days intragastrically,then obtaining the peripheral lymphocytes,preparing surspension which contains IL-2 for assay by method MTT. Results: The IL-2 activity of mice pheripheral blood is increased from 24 to 48h after innoculation, reaching over 50% of secreting activity,and it has a significant differences (PO. 01 )from control. After 48h the IL-2 activity begins to derease. After 96h the IL-2 activity becomes normal. Meanwhile administration by oral is the only pathway for sepia to induce the secretion of IL-2 in mice.
【CateGory Index】: R285
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