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《Chinese Journal of Marine Drugs》 2001-01
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Study on the induction of IFN γ and LAK cells activity in mice stimulated with sepia

WANG Qun,Lü Chang long,Lü Chao, et al (Department of Immunology,China Medical University,Shenyang 110001)  
To investigate the effects of sepia on immunologic functions,the levels of IFN γ in sera of mice stimulated with sepia were determined by ELISA.In addition,the killing tumor activity in vitro of LAK cells was evaluated with biological method.The results showed that the level of IFN γ in the test groups began to increase at 24h after administration by oral,and the peak value appeared at 48h,and after 72h the level of IFN γ became normal.There was significant difference between the test and control groups in the killing activity of LAK cells( P 0.01).It was demonstrated further that sepia could induce the production of various cytokines and enhance the activity of immunocompetent cells.
【CateGory Index】: R285
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