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《Chinese Journal of Marine Drugs》 2003-05
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Study on Secretion of Interleukin-1 Induced by Sepia in Mice

HE Shen, MENG Sheng-nan, XIE Guang-lin. (College of Basic Medical Science, China Medical University, Shenyang 110001, China)  
Objective To investigate secretion of interleukin-1 (IL-1) in BALB/C mice macro-phage induced by sepia. Methods Ascitic fluid was drawed out after sepia was poured into mice intragastrically and the biologic activity of IL-1 induced in mice macrophage was examined by fibroblast proliferation experiment. Duration of IL-1 secretion and the concentration- activity relation in vivo were also studied. Results Sepia can induce IL-1 in BALB/C mice macrophage. The effects had significant differences compared with control group. Tracking detection in vivo displayed IL-1 had the highest secretion at the second day after stopped inducing and also secretion evidence at the fifth day and reached to normal at the ninth day. The IL-1 activity of original-detected liquid had not decreased at 8 fold dilution and approach normal at 32 fold. Conclusion Sepia can induce IL-1 in BALB/C mice macrophage, and it had shown the highest secretion was at 48 hours.
【CateGory Index】: R96
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