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《Chinese Journal of Marine Drugs》 2004-04
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Effects of squid ink on the NO production and IFN-γSecretion by spleen cells and macrophages in mice

YAN Jian-zhong, LU Chang-long, LI Wei, NA Li-xin, LIU Jun, TAN Ying-hui, CAO Ya-ming Department of Immunology , China Medical University, Shenyang 110001, China  
Objective To investigate the nitric oxide(NO) and interferon-γ(IFN-γ) levels produced by spleen cells and macrophages in mice treated orally with squid ink. Methods Griess and ELISA assay were used respectively to detect quantitatively NO and IFN-γ in the culture medium of macrophages and spleen cells from mice after the treatment of squid ink. Results NO level produced by peritoneal macrophage and spleen cell from the mice was increased significantly compared to the control and IFN-γ level by the spleen cells was also relatively higher on the day 4 and 6 after the treatment of squid ink. The positive correlation (r=0. 98) was seen between the levels of NO and IFN-γ secreted by the spleen cells. LPS showed the activity promoting the production of NO in coordination with IFN-γ. Conclusion The squid ink is able to promote the production of NO in macrophages. There was a positive correlation between the levels of NO and IFN-γ produced by spleen cells from the treated mice with squid ink.
【Fund】: 由上海澳博海洋生物技术开发有限公司资助。
【CateGory Index】: R285
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