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《Chinese Journal of Marine Drugs》 2005-01
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Anti-tumor effect of Haishengsu extracted from Tegillarca granosa in vitro and in vivo

YAO Ru-yong 1, CHU Xiao 2, ZHANG Yu-jiang 3, YANG Xiu 4, LIU Xiu-rong 4, WANG Chun-bo 3(1. The Affiliated Hospital of Medical School, Qingdao University; 2. Qingdao Municipal Hospital; 3. Medical School, Qingdao University; 4. Haisheng Oncology Hospital of Qingdao, Qingdao 266003, China)  
Aim To study the infuences of Haishengsu extracted from Tegillarca granosa on cultured tumor cells of lung cancer, breast cancer and carcinoma of stomach from human in vitro and its preventive antitumor effect on transplanted tumor in mice in vivo. Methods The inhibitory effect of Haishengsu on tumor cells proliferation was assayed by MTT method, and transplant tumor models of sarcoma 180 (S 180), Ehrlich ascites carcinoma (EAC), and hepatoma (Heps) were used. Before and after transplantation, different doses of Haishengsu were given to the mice for 10 days. The inhibition rates and life span of the mice were calculated. Results Haishengsu at concentrations of 0.5%~2.0% inhibited the proliferation of tested tumor cells in vitro,especially on lung cancer cells with a dose dependent manner (r= 0.974,P0.01). The inhibition rates of Haishengsu injection (147~300 mg·kg -1) were 19.34%~65.19% and 32.23%~79.53% in tumor-bearing mice with S 180 and hepatoma respectively. Haishengsu injection prolonged the life span of EAC-bearing mice by 40.54%~57.66%. Conclusion Haishengsu could inhibit the proliferation of three kinds of tumor cells in vitro and showed preventive antitumor effect on the tumor-bearing mice in dose-dependent manner without adverse effects.
【Fund】: 青岛市科技局科技三项经费项目(99青科技字028号)
【CateGory Index】: R73-3
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