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《Chinese Journal of Marine Drugs》 2006-05
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Effects of sepia on hematopoietic stem cells,granulocyte and monocyte progentior cells and peripheral WBC in mice

LEI Min,WANG Jing-feng,PANG Long,GAO Sen,WANG Yi,XUE Chang-hu(Ocean University of China,Qingdao 266003,China)  
Objective To investigate the effects of sepia on stem cells,granulocyte and monocyte progentior cells and peripheral WBC in mice.Methods Different dosages of sepia were given to normal and model mice with hematopoietic system impairment respectively.The numbers of CFU-S,CFU-GM and peripheral WBC in normal and model mice were measured respectively with the method of hematopoietic progenitor cells cultured in vitro and the technique of experimental hematology.Results Sepia could enhance the number of CFU-S,CFU-GM and peripheral WBC in normal mice significantly,resist the decrease of CFU-S,CFU-GM,and peripheral WBC in model mice of hemapoiecsis impaired effectively and promote the restoration of those indices mentioned above in model mice significantly.Conclusion Sepia has significant effects on stimulating granulopoiesis in bone marrow in mice.The mechanism may be related to regulating immunological function and inducement GM-CSF and other sorts of cellular factors,which in turn promote the multiplication differentiation of CFU-S and CFU-GM.
【Fund】: 新世纪优秀人才支持计划项目(NCET-04-0642);; 国家自然科学基金项目(No.30471319)
【CateGory Index】: R96
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