Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Marine Drugs》 2008-04
Add to Favorite Get Latest Update

Antitumor screening of deep ocean water and sediment derived fungi and primary investigation of their secondary metabolites

ZHAO Boyu ZHU Tian-jiao FANG Yu chun GU Qian qun~* ZHU Wei-ming (Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China)  
Objective The cytotoxic microbial strains isolated from the deep ocean water and sediments were screened,and the secondary metabolites of bioactive fungus c2b were investi- gated.Methods Active bioactive microbial strains were screened using brine shrimp and chro- nic medulla leucocythemia leukocythemia(K562)cell line.The cytotoxic components of fun- gus c2b were isolated by bioassay-guided fractionation and solvent extraction,silica gel col- umn chromatography and preparative HPLC.Their structures were established by pbysico- chemical properties and spectral analyses.The cytotoxicities of compounds were evaluated by SRB method.Results and Conclusion Twenty-nine strains of fungi were isolated.Among them,seven strains showed cytotoxic activities.Six compounds(1~6)were isolated and i- dentified as N-acetyl histamine(1),chrysogine(2),ergosterol peroxide(3),5,8-epidioxy- 24-methylcholesta-6,22-dien-3β-ol(4)cerevisterol(5)and(4E,8E)-N-[(2'R,3'E)-2'-hy- droxy-3'-hexadecenoyl]-1-O-β-D-glycopyranosyl-9-methyl-4,8-sphingadiene(6),respective- ly.Compound 3 and 4 showed median cytotoxicity.
【Fund】: 中国大洋矿产资源研究开发协会资助项目(DY105-2-04-02)
【CateGory Index】: R284
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 Zhang zhihua1 et al. ( 1 Xinzhou vocational technical college,Xinzhou 034000,2 Dingxiang people’s hospital,Dingxiang 035400);Research Review on Bioactive Substances of Marine Fungi[J];Anhui Agricultural Science Bulletin;2010-11
2 ZHOU Jing,CHEN Min,LI Yun,LIU Yun-zhang,WANG Chang-yun(Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy, Ocean University of China,Qingdao 266003,China);Secondary metabolites from a fungus Peniophora sp.isolated from a gorgonian Echinogorgia sp.[J];Chinese Journal of Marine Drugs;2012-04
3 LIU Tao1,LI Zhan-lin2,WANG Yu2,TIAN Li3,4,PEI Yue-hu2,HUA Hui-ming2 1School of Pharmaceutical Sciences,China Medical University,Shenyang 110001,China;2Key Laboratory of Structure-Based Drug Design & Discovery,Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China;3The First Institute of Oceanography SOA,Qingdao 266061,China;4Qingdao University of Science & Technology,Qingdao 266042,China;Secondary Metabolites from Marine Fungus Fusarium sp.[J];Natural Product Research and Development;2012-08
【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHAO Chang-Hui YE De-Zan WEI Wen-Ling (School of Life Sciences, Xiamen University, Xiamen 361005) (Key Laboratory of State Oceanic Administration ( SOA) for Marine Biogenetic Resources Third Institute of Oceanography, Xiamen 361005);Research on Deep-sea Microbiology[J];Microbiology;2006-03
2 Xiao Xiang and Wang Feng-ping(Third Institute of Oceanography,State Oceanic Administration,Xiamen 361005);Research and development of deep-sea microbes[J];Chinese Journal of Antibiotics;2006-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 XIA Jian-xin,LI Chang,MA Yan-fang(College of Life and Environmental Science,Central University of Nationalities, Beijing 100081,China);DEEP-SEA HYDROTHERMAL ACTIVITY:A HOT RESEARCH TOPIC[J];Journal of Geomechanics;2007-02
2 LI Ming,YE Dezan,HUANG Xiangling (The Third Institute of Oceanography,SOA;Key Laboratory of SOA for Marine Biogenetic Resources,Xiamen 361005);A PRIMARY STUDY ON POPULATION BIODIVERSITY OF MARINE MICROORGANISMS FROM EAST PACIFIC[J];Transactions of Oceanology and Limnology;2008-02
3 WANG Xue-mei1,2,HU Jiang-chun1,WANG Shu-jin11.Institute of Applied Ecology,Chinese Academy of Sciences,Shenyang 110016,China;2.Graduated School of Chinese Academy of Sciences,Beijing 100049,China;Identification of the Protease-Producing Strain B1394 and Characterization of the Protease[J];Journal of Jilin Agricultural University;2009-02
4 Zhao Yongkun Yu Huahong Yang Meng (The Key Laboratory of Food Science(Nanchang University),Ministry of education;College of Life Sciences, Nanchang university,Nanchang 330047);Research and Application Development of Bioactive Products of Microorganisms[J];Jiangxi Food Industry;2007-04
5 WANG Shu-jun1,2,LU Zhao-xin1,Lü Ming-sheng2,LIU Hong-fei2,XU Jin-li2,YANG Lei2 (1.College of Food Science and Technology,Nanjing Agricultural University,Nanjing 210095,China;2.Jiangsu Key Laboratory of Marine Biotechnology/College of Food Engineering,Huaihai Institute of Technology,Lianyungang 222005,China);Identification and hyperthermophilic enzyme activities of a hyperthermophilic archaeon isolated from deep-sea hydrothermal vent[J];Journal of Nanjing Agricultural University;2009-02
6 JIANG Bing-guo (Chinese Academy of Fishery Sciences,Beijing 100141, China);Industrialization Mode and Development Countermeasures for the Deep-sea Microbe in China[J];Marine Economy;2012-03
7 JI Qian, ZHANG Jing State Key Laboratory of Estuarine and Coastal Research, East China Normal University, Shanghai 200062;Optimization in Pretreatment Conditions for Determination of Heterotrophic Bacteria from Freshwater and Marine Sediments Using Flow Cytometry[J];Asian Journal of Ecotoxicology;2008-03
8 WANG Xiang-min1,2 YE De-zan1,2 LIN Wen-han3 LI Ming1,2 SUN Jia1,2 HUANG Xiang-ling1,2(1 Key Laboratory of Marine Biogenetic Resources of SOA,Xiamen 361005,China)(2 Third Institute of Oceanography of SOA,Xiamen 361005,China)(3 State Key Laboratory of Natural and Biomimetic Drugs,Peking Universtiy,Beijing 100083,China);A Primary Study on Antitumor Activity of Deep-sea Microorganisms Isolated from the Tropical Pacific Ocean[J];China Biotechnology;2007-10
9 Zhuang Ling~(1,2) Hong Kui~1 (1 Institute of Tropical Biosciences and Biotechnology,Chinese Academy of Tropical Agricultural Science,Haikou 571101;2 College of Plant Protection,South China University of Tropical Agriculture,Danzhou 571737);Research of Screening of Anti-MRSA Activity and Test the Halophilic and Halotolerant of 24 Deep-sea Streptomyces[J];Biotechnology Bulletin;2009-S1
10 QIN Yan-hong,YE De-zan(Key Laboratory of Marine Biogenetic Resource/Third Institute of Oceanography,SOA,Xiamen 361005,China);Simple methods for screening the oceanic oleaginous microorganisms[J];Journal of Oceanography in Taiwan Strait;2010-01
China Proceedings of conference Full-text Database 1 Hits
1 CAI Sheng-xin,ZHAO Bo-yu,ZHU Tian-jiao,GU Qian-qun *(Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China);Antitumor screening of deep ocean water and sediments derived fungi and primary investigation of their secondary metabolites[A];[C];2008
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 GUAN Hong-xiang1,2 CHEN Duo-fu1 Cathles L M3 Roberts H H4(1.Key Laboratory of Marginal Sea Geology,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Wushan,Guangzhou Guangdong 510640;2.Graduate School of the Chinese Academy of Sciences,Beijing 100039;3.Department of Earth & Atmospheric Sciences,Cornell University,Ithaca,New York 14853,USA;4.Coastal Studies Institute,Louisiana State University,Batton Rouge,LA 70803,USA);Microstructure and Fossilized Bacteria in Seep Carbonates from An Active Gas Vent in Green Canyon Block 238 of Gulf of Mexico[J];Acta Sedimentologica Sinica;2008-01
2 JIAO Bing-hua(Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China);Research and development of marine bio-active substances and drugs[J];Academic Journal of Second Military Medical University;2006-01
3 Lu Baozhong;The construction of molecular evolutionary trees[J];Zoological Research;1993-02
4 CHEN Jian fang 1,2 (1.Key Lab of Submarine Geosciences, Second Institute of Oceanography, SOA, Hangzhou 310012,China; 2.Laboratory of Marine Geology of MOE,Tongji University, Shanghai 200092,China);NEW GEOCHEMICAL PROXIES IN PALEOC-EANOGRAPHY STUDIES[J];Advance In Earth Sciences;2002-03
5 ZHANG Hongxiang1,2, ZHAO Qianjun2, GUO Lin2(1. Geology and Geophysics Institute of Chinese Academic Sciences, Beijing 100101,China; 2.Bureau of Science and Technology for Resources and Environment, Chinese Academic Sciences, Beijing 100864,China);DEEPSEA HOT SPRINGS CREATURESTHE HUMAN BEING's GENIC RESOURCE THESAURUS[J];Advance In Earth Sciences;2002-06
6 XI Feng~(1,2), ZHENG Tian-ling~1, JIAO Nian-zhi~1,ZHANG Yao~1(1.Applied Environment Microorganism Graduate School,Life Science Institute,Xiamen University,Xiamen 361005,China;2.Environment Science Research Center, Marine and Environment Institute, Xiamen University,Xiamen 361005,China; 3.Aquaculture Biological Technique Institute, Jimei University, Xiamen 361021, China);A PRELIMINARY ANALYSIS OF MECHANISM OF DEEP SEA MICROORGANISMS DIVERSITY[J];Advance in Earth Sciences;2004-01
7 LI Tao,WANG Peng,WANG Pin-xian(State Key Laboratory of Marine Geology,Tongji University,Shanghai 200092,China);A Preliminary Study on the Diversity of Bacteria in the Xisha Trough Sediment,the South China Sea[J];Advances in Earth Science;2006-10
8 SUN Song,SUN Xiao-xia(Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China);Census of Marine Life[J];Advances in Earth Science;2007-10
9 WANG Liling1,2,LIN Jingxing3,HU Jianfang1(1.State Key Laboratory of Organic Geochemistry,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640,China;2.Graduate University of Chinese Academy of Sciences,Beijing 100049,China;3.Research Center of Contemporary Ecoenvironmental Geology,Institute of Geology,Chinese Academy of Geological Sciences,Beijing 100037,China);Recent Progress in Deep-sea Hydrothermal Vent Communities[J];Advances in Earth Science;2008-06
10 SU Jing Yu, YAN Su Jun, ZENG Long Mei  (Department of Chemistry, Zhongshan University, Guangzhou 510275, China);A New Diterpene Lactone from the Soft Coral Sarcophyton molle Tix. Dur.[J];Chemical Research In Chinese Universities;2001-09
China Proceedings of conference Full-text Database 1 Hits
1 Hong Liang~(1,2) Hong Kui~1 1 Institute of Tropical Biological Sciences,Chinese Academy of Tropical Agricultural Science,State Key Lab for Tropical Crops Biotechnology,Haikou,571101;2 Engineering School,South China University of Tropical Agriculture,Danzhou,571737;Diversity of Marine Fungi and their Antitumor Bioactive Substances[A];[C];2005
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 SHANG Zhuo1,2,WANG Bin-Gui1*(1 Key Laboratory of Experimental Marine Biology,Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China;2 Graduate School of Chinese Academy of Sciences,Beijing 100039,China);Methods and advances in studies on antimicrobial substances of marine-derived fungi[J];Chinese Bulletin of Life Sciences;2012-09
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 YI Yang Hua 1,LI Ling 1,LIN Hou Wen 1,LI Wen Lin 1,YAO Xin Sheng 2,TANG Hai Feng 1,XU Qiang Zhi 1,ZOU Zheng Rong 1,SUN Peng 1,ZHANG Shu Yu 1,LIU Bao Shu 1 (1. Research Center for Marine Drugs,College of Pharmacy,Second Military Medical;Studies on antineoplastic constituents from marine organisms in south China sea[J];Academic Journal of Second Military Medical University;2002-03
2 XU Xiu-li 1,3 ,FAN xiao 1 ,SONG Fu-hang 1,3 ,SHI Jian-gong 2 (1.Institute of Oceanology,Chinese Academy of Sciences,Qingdao266071,China;2.Institute of Materia Medica,Chiˉnese Academy of Medical Sciences and Peking Union Medical College,Beijing100050,China;3.Graduate School of the Chinese Academy of Sciences,Beijing100039,China);Isolation and structure elucidation of four compounds from brown alga Leathesia nana[J];Marine Sciences;2004-05
3 YAN Xiao-hong 1,GUO Yue-wei 1*,SONG Guo-qiang 1,MOLLO Ernesto 2,CIMINO Guido 2 (1.State Key Laboratory of Drug Research,Institute of Materia Medica,Shanghai Instituent for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China; 2.Istituto di Chimica Biomolecolare-CNR,Napoli,Italy);STUDIES ON THE CHEMICAL CONSTITUENTS OF MARINE SPONGE IOTROCHOTO SINUSTYLA FROM THE SOUTH CHINA SEA[J];Natural Product Research and Development;2003-04
4 LUO Zhu hua, HUANG Xiang ling, WANG Lin, PEI Yao wen, YE De zan (The Key Laboratory of State Oceanic Administration(SOA) for Marine Biotechnology/Third Institute of Oceanography, SOA, Xiamen 361005,China);Screening of marine bacteria with antimicrobial activity[J];Journal of Oceanography In Taiwan Strait;2002-02
5 ZHAO Chang-Hui YE De-Zan WEI Wen-Ling (School of Life Sciences, Xiamen University, Xiamen 361005) (Key Laboratory of State Oceanic Administration ( SOA) for Marine Biogenetic Resources Third Institute of Oceanography, Xiamen 361005);Research on Deep-sea Microbiology[J];Microbiology;2006-03
6 ZHANG Yong-jie, WANG Jian-feng, HUANG Yao-jian, ZHENG Zhong-hui, SU Wen-jin(School of Life Science, Xiamen University, Xiamen 361005, China);Screening for Antitumor Activities of Endophytic Fungi Isolated from Four Species of Gymnoperm[J];Journal of Xiamen University(Natural Science);2002-06
7 DING Zhi-Hui, HE Yun-Ping, DING Jing-Kai (Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, China);THE CHEMICAL CONSTITUENTS OF LYSIMACHIA MICROCARPA[J];Acta Botanica Yunnanica;1993-02
8 XIONG Jiang 1,ZHOU Jun 1* ,DAI Hao Fu 1,TAN Ning Hua 1,DING Zhong Tao 2 (1 Laboratory of Phytochemistry, Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China; (2 Department of Chemistry,Yunnan University,Kunming 650091;Chemical Constituents from Phytolacca polyandra[J];Acta Botanica Yunnanica;2002-03
9 Wang Youchu(Wang YC), Zhou Jun(Zhou J), Tan Ninghua(Tan NH), Ding Zhongtao(Ding ZT) and Jiang Xin(Jiang X) (Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204);CYCLIC DIPEPTIDES FROM SCHIZANDRA CHINENSIS AND THEIR SYNTHESES[J];ACTA PHARMACEUTICA SINICA;1999-01
10 Li Yiqing;Yi Yanghua;Tang Haifun;et al( Address: Li Yiqi7ng,School of Phrmacy,Th Second Miltary Medical Unlversity,Shanghai);Studies on the Chemical Constituents of Glabrous Greenbrier(Smilax glabra)[J];Chinese Traditional and Herbal Drugs;1996-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved