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《Chinese Journal of Marine Drugs》 2011-01
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Pharmacological researches of Syngnathus acus Linnaeus on mouse benign prostatic hyperplasia model induced by fetal urogenital sinus implants

XU Dong-hui,JIANG Guo-jin,MEI Xue-ting,XU Shi-bo(Lab.of Chinese Medicine and Marine Drugs,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China)  
Objective To study the effects of Syngnathus acus Linnaeus on mouse benign prostatic hyperplasia(BPH) induced by fetal urogenital sinus implants,and to investigate the possibility of applying Syngnathus acus Linnaeus to BPH treatment.Methods Mouse BPH model was established by implanting 16 days old embryo urogenital sinus of mouse.After oral administration of Syngnathus acus Linnaeus(50,100,200 mg.kg-1) for 30 days,the indices of seminal vesicle and prostatic weight,serum acid phosphatase(ACP),prostatic gland perimeter,gland area and gland epithelial height of mice were measured.Results Compared to BPH model group,oral administration of Syngnathus acus Linnaeus reduced the prostatic weight,serum ACP,prostatic gland perimeter,gland area and gland epithelial height,and increased the index of seminal vesicle.Conclusion As a traditional drug for invigorating the kidney and strengthening Yang,increasing number of sperms,Syngnathus acus Linnaeus showed therapeutic effects on BPH,hence could be developed a marine drug for treatment of BPH without side effects such as impotence and oligospermatism.
【Fund】: 国家海洋863重点项目(2006AA090404)
【CateGory Index】: R285.5
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