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《Chinese Journal of Marine Drugs》 2012-01
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Effect of Sipunculus nudus polysaccharides on immunological function in mice

LI Ke-xian,SHEN Xian-rong*,HE Ying,JIANG Ding-wen,LIU Yu-ming,HOU Deng-yong,CHEN Wei(Naval Medical Research Institute,Shanghai 200433,China)  
Objective To investigate the effect of Sipunculus nudus Polysaccharides(SNP)on immunological functions in mice.Methods By lymphocyte transformation test and NK cells activity test,the effects of SNP on cellular immunity were evaluated.By the hemolysin level of serum and plaque-forming cell(PFC) test of mice sensitized by sheep red blood cell(SRBC),the effect of SNP on humoral immunity was measured.Carbon clearance test was used to detect the promotion of phagocytosis function caused by SNP.Results Compared with the normal group,SNP could promote the cellular immunity and humoral immunity,and promote eyewinker's phagocytosis function of liver and spleen in mice.Conclusion SNP can stimulate the immunological function in mice.
【CateGory Index】: R285.5
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