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《Chinese Journal of Marine Drugs》 2012-05
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Effects of sepia ink polysaccharides on spermatogenesis injured by cyclophosphamide

LE Xiao-yan1,XU Ze-xuan1,SHI Li-sha1,LIN Shao-jie1,YUAN Lin1,LIU Hua-zhong2(1.Faculty of Food Science and Techology,Guangdong Ocean University,Zhanjiang 524088,China; 2.Biochemistry Center,Guangdong Ocean University,Zhanjiang 524088,China)  
Objective To investigate the protective effects of sepia ink polysaccharides on spermatogenic lesion induced by cyclophosphamide.Methods Male Kunming mice were equally allotted to groups,and were intraperitoneally injected with cyclophosphamide(CP,15mg/kg) once a week for 10 weeks to construct injured model of spermatogenesis by CP.Mice in treatment groups orally received sepia ink polysaccharides once a day for 10 weeks.Quantity,survival rate and abnormal rate of sperm and SOD enzyme activety were determined and compared with those of model group.Results Sepia ink polysaccharides,apart from sperm quantity(P0.05),weakened the negative effects of cyclophosphamide on sperm survival rate and abnormal rate and SOD enzyme activety(P0.01).Conclusion Sepia ink polysaccharides have a protective effect on the spermatogenic lesion induced by cyclophosphamide.
【Fund】: 国家自然科学基金项目(31171667);; 广东省大学生创新实验项目(1056610024)资助
【CateGory Index】: R285.5
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