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《Journal of Medical Forum》 2004-07
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Study on Stability of Compatibility of Cefuroxime Sodium Injection with 6 Drugs

ZHANG Yuyun, ZHENG Wenping ,ZHENG Yihui, et al Department of pharmacy,the Second Affiliated Hospital,Medical College of Shantou University,Shantou 515041,China  
Objective To Study the compatible stability of cefuroxime sodium injection with 6 drugs under temperature 25℃ and 37℃.Methods Uv-vis was applied to the quantitation analysis of cefuroxime sodium injection with 6 drugs,pH and the aspect was observed too.Changes after mixing in appearance,pH and the contents of cefuroxime sodium were determined.Results The mixture of cefuroxime sodium injection with aminophylline resulted in significant drop in pH and the contents of cefuroxime sodium;with yuxingcao injection in marked increased pH;with other 4 drugs(ambroxol hydrochloride injection,clindamycine injection,aminomethylbenzoic acid injection,yinzhihuang injection)no significant change was found.Conclusion Cefuroxime sodium injection could not be compatible with aminophylline injection and could be compatible with yuxingcao injection with caution,could be compatible with other 4 drugs injection.
【CateGory Index】: R942
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【Secondary References】
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1 Department of Pharmacy, Hefei No.4 People's Hospital, Hefei 230022,Anhui YANG Shu-guang;Stability of Cefuroxime Sodium with the Common Used Liquid in the Clinical[J];Journal of Anhui Health Vocational & Technical College;2008-04
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Chinese Journal Full-text Database 1 Hits
1 Cao Xiuqin,Li Xuenlng'.Xu Yi* ,et at (Department of Pharmacy,Shanghai 5th People'sHospital,Shanghai 200240; Department of clinical Pharmacology,Zhongshan Hospital of Shanghai Medical University,Shanghai 200032);Determination of cefuroxime in serum by HPLC[J];Chinese Journal of Clinical Pharmacy;1998-04
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