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《Journal of Medical Forum》 2008-18
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Significance of Testing Serum Levels of IL-1β、IL-6 and TNF-α in RA Patients

ZHU Minghui,YANG Yi,LIU Xuhua,et al The Fifth People's Hospital of Zhengzhou City,Zhengzhou 450003,China  
Objective To explore the role of cytokines such as IL-1β、IL-6 and TNF-α in the RA pathogenesis function through the determination RA patient and the normal control group serum levels of the cytokines.Methods Gathering 20 RA patients dividing into two groups and 10 heathy people as normal comparative group,each of them adopt ELISA to test the serum level of IL-1β、IL-6 and TNF-α.Results Comparing MTX+TGP+LEF group and MTX group,the former curing effect is obviously better than the latter one.Before the treatment,the higher level of IL-1β、IL-6 and TNF-α in the serum of RA patients than the normal comparative group on average has obviously statistic significance.After the treatment,copmaring the changing level of IL-1β、IL-6 and TNF-α during the treatment in the two RA patients groups has obviously statistic significance.Conclusion IL-1β、IL-6 and TNF-α play an important part in patients's getting sickness and development.
【CateGory Index】: R593.22;R446.6
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