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《Journal of Medical Forum》 2019-09
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Efficacy evaluation of Shuganjieyu capsule in treatment of patients with essential hypentension and anxiety

XIONG Yan-xia;LI Jun-kai;LI Yan-mei;SONG huan-huan;ZHANG Yan-ping;YANG Hai-yan;The First Affiliated Hospital of Henan University of TCM;  
Objective To evaluate the clinical efficacy of Shuganjieyu capsule in the treatment of essential hypertension and depression.Methods Sixty patients with essential hypertension and depression were screened by dp/dtlvmax and ABPM. They were randomly divided into experimental group and control group. On the basis of conventional antihypertensive treatment, the experimental group was given Shuganjieyu capsule(2 capsules, bid).The control group received conventional antihypertensive drugs.Results After 4 weeks of treatment,the mean systolic blood pressure(132.60±9.81)mm Hg, 24-hour mean diastolic blood pressure(65.40±9.81)mm Hg, and the maximum change rate of left internal pressure [male:(1 534.38±136)mm Hg; female:(1 295.88±185.44)mm Hg], anxiety scale score(33.40±2.40) were significantly lower than that of the control group [24-hour mean systolic blood pressure(156.40±8.18)mm Hg, 24-hour mean diastolic blood pressure(94.47±5.20)mm Hg, maximum change rate of left indoor pressure [male:(1807.21±238.71); female:(1741.88±204.25)], anxiety scale score(44.60±2.03)], the difference was statistically significant(P0.01).Conclusion Shuganjieyu capsule combined with conventional antihypertensive therapy for patients with hypertension and depression is significant.
【Fund】: 河南省中医药科学研究专项课题(2016ZY038)
【CateGory Index】: R544.11;R749.72
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