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《Journal of Medical Forum》 2019-09
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Observation of effect of palipiperidone combined with transcranial magnetic stimulation in treatment of refractory schizophrenia

JIAO Xiu-juan;XU Dong;Department of Psychiatry, Zhengzhou the Eighth People's Hospital;  
Objective To observe the therapeutic effect of palipiperidone combined with repeated transcranial magnetic stimulation(rTMS) on refractory schizophrenia. Methods In May 2016 to May 2018 in zhengzhou city, the eighth people's hospital treat 100 patients with treatment-resistant schizophrenia, each group 50 cases, they were divided into observation group and control group, both groups using peary pp methadone treatment, the observation group on the basis of the control group added rTMS treatment, to observe the clinical efficacy of two groups of patients, personal and social function scale(PSP) score and symptom scale(TESS) adverse reaction.Results After 8 weeks of treatment, the effective rate and PSP scale scores of the observation group were 90.00% and(60.36±9.26) points, respectively, which were significantly higher than those of the control group(74.00% and(49.22±7.46) points), and the difference was statistically significant(P0.05). Adverse reactions, such as lethargy, tachycardia, gastrointestinal reactions, insomnia, liver dysfunction, were 6 cases(12.00%), 4 cases(8.00%), 6 cases(12.00%), 5 cases(10.00%), 1 case(2.00%) in the observation group, and 8 cases(16.00%), 6 cases(12.00%), 9 cases(18.00%), 6 cases(12.00%), 1 case(2.00%) in the control group, respectively. There was no significant difference in the incidence of adverse events between the two groups(P0.05). Conclusion For patients with refractory schizophrenia, palipiperidone combined with rTMS can significantly improve the therapeutic effect and improve the social function of patients with high safety.
【CateGory Index】: R749.3
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