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Effect of Gypenosides against Oxidative Damage. Part Ⅱ the Influence of Gypenosides on Cerbrovascular Injury Induced by Free Radicals.

Liao Duan Fang,et al Department of Pharmacology  
We investigated the protective effect of gypenosides(GPS) against cerebrovascular damage due to oxygen free radicals. In the acute ischemia cerebral thrombsis of rats induced by injecting into carotid artery a mixture of ADP,thrombin and epinephrine,GPS l00mg/kg ip had a protective effect on cerbrovascular integrity as shown by a reduction of evens blue concentration (0.035±0.009 vs 0.059+0.010,p 0.01) and malonialdehyde content (4.08±0.20vs 5.50±0.66nmol/mg wet wt,p 0.01) in the infarct hemisphere. In the isolated rabbit basial arteries, Krebs solution electyolyzed by 30 s and 1 min(5mA) promoted markedly perfusion pressure to 2.74±0.49 Kpa and 6.91±0.39 Kpa respectively. GPS 100μg/ml significantly inhibited the rise of perfusion pressure (0.54±0.05 vs 2.74±0.49 Kpa,P0.05 and 0.96±0.05 vs 6.91±0.39 Kpa,P0.01). It was concluded that GPS could protect from cerebrovascular injury due to OFR.
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