Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《》 1993-03
Add to Favorite Get Latest Update

Effect of Gypenosides against Oxidative Damage. Part Ⅱ the Influence of Gypenosides on Cerbrovascular Injury Induced by Free Radicals.

Liao Duan Fang,et al Department of Pharmacology  
We investigated the protective effect of gypenosides(GPS) against cerebrovascular damage due to oxygen free radicals. In the acute ischemia cerebral thrombsis of rats induced by injecting into carotid artery a mixture of ADP,thrombin and epinephrine,GPS l00mg/kg ip had a protective effect on cerbrovascular integrity as shown by a reduction of evens blue concentration (0.035±0.009 vs 0.059+0.010,p 0.01) and malonialdehyde content (4.08±0.20vs 5.50±0.66nmol/mg wet wt,p 0.01) in the infarct hemisphere. In the isolated rabbit basial arteries, Krebs solution electyolyzed by 30 s and 1 min(5mA) promoted markedly perfusion pressure to 2.74±0.49 Kpa and 6.91±0.39 Kpa respectively. GPS 100μg/ml significantly inhibited the rise of perfusion pressure (0.54±0.05 vs 2.74±0.49 Kpa,P0.05 and 0.96±0.05 vs 6.91±0.39 Kpa,P0.01). It was concluded that GPS could protect from cerebrovascular injury due to OFR.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 Zhu Bingyang(Zhu BY),Tang Xiaoqing(Tang XQ),Huang Honglin(Huang HL),et al(Division of Cardiopulmonary Pharmacology, Hengyang Medical College,Hengyang 421001);Protective effect of gypenosides on brain ischemia induced by photochemical occlusion of middle cerebral artery in rats[J];Chinese Journal of Modern Applied Pharmacy;2001-01
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Liao DuanFang, Department of Pharmacology and Physiology, Hengyang Medical College;Effect of Gypenosides Against Oxidative Damage Part I, Influence of Gypenosides on Free Radicals Induced Injury of Guinea Pig Papillary Muscles And Rabbit Arterial Endothelium in Vitro[J];;1993-01
2 WANG Zhu-Yun, QIU Pei-LunDepartment of Pharmacology, Xi'an Medical University, Xi'an 710061;Protective effect of gypenosides on acute incomplete cerebralischemia in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1992-03
3 YH Zhou, JJ Shen, RG Wang, QS Yang, SF Zhao and YY Jin (Departmeot of Pharmacology, Capital Institute of Medicine, Beijing);EFFECTS OF CINNARIZINE ON RABBIT PLATELET AGGREGATION AND EXPERIMENTAL CEREBRAL THROMBOSIS IN RATS[J];Acta Pharmaceutica Sinica;1988-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YU Sheng1,LV Gui-yuan1,CHENG Su-hong2(1.Zhejiang University of Traditional Chinese Medicine,Hangzhou 310053,China;2.Wenzhou Medical College,Wenzhou 325035,China);Related pharmacological research of hippocampus's efficacy on nature,flavor,meridian tropism[J];Anhui Medical and Pharmaceutical Journal;2009-05
2 He Ying;Wang Dongwu;Den Zhikuan(Department of Neurology,Xinqiao Hospital,Third Military Medical University,Chongqing,630038)Zhang Wei(Department of Statistics, Third Military Medical University,Chongqing,630038);Changes of intracellular calcium content and cerebral ultrastructures after brainstem ischemia in dogs[J];ACTA ACADEMIAE MEDICINAE MILITARIS TERTIAE;1996-02
3 Yu Juan;Yang Shanzhang(Department of Pathophysiology,Fujian Medical College,Fuzhou,350004);Observation of Effects of Gynostemma Pentaphyllum on Platelet Disaggregation in Human[J];;1995-03
4 SHE Jia heng 1 DAI Jian ping 2(1.The Second the people's Hospital of Fujian.;2.Fuzhou Likrng Technical Development Application co.ltd);Effect of Shuangsationg and Venoruton on Rabbit Platelet Aggregation and Expcrimental Cerebral Thromhosis in Rats[J];Strait Pharmaceutical Journal;2001-03
5 LiShu-Xiu et al(Zhengzhou Health School,Zhengzhou,Henan,45005 2);TBE EFFECTS OF BERBERINE ON EXPERIMENTAL MICE THROMBOSIS[J];HENAN MEDICAL RESEARCH;1994-01
6 Xu Donghui, Xu Shibo (Department of Pharmacy, Zhongshan University, Guangzhou 510275);THE EXTRACT FROM HIPPOCAMPUS TRIMACULATUS (EHT): ITS EFFECT OF ANTITHROMBOSIS IN RATS AND INGREDIENTS ANALYSIS[J];Chinese Journal of Marine Drugs;1997-01
7 Tang Chaoke, Sun Ming, Wen Gebo, Hu Bi, Liao Duanfang (Department of Diagnostics of Hengyang Medical College, Hengyang, 421001);Effect of Gypenosides on Mean Arterial Pressure and Nitric Oxide Levels in Rabbits with Endotosin Induced Shock[J];JOURNAL OF HENGYANG MEDICAL COLLEGE;1999-04
8 Lei Jianhua;et al(Department of Physiology Hengyang healthy academy,Hengyang,Hunan);Preventive Effect of Gypenoside Against Endotoxic Shock-Induced DIC in rabbit[J];JOURNAL OF HENGYANG MEDICAL COLLEGE;1994-02
9 T C M College,Hebei Medical UniversityTIAN Shu xiao ZHU Chang fu WANG Xin guo et al(050091);The research & methodology exploration on atheroscleorsis and its relative diseases[J];JOURNAL OF HEBEI TRADITIONAL CHINESE MEDICINE AND PHARMACOLOGY;2000-03
10 Ni Shoudong(The First Hospital of Chaohu City, Anhui Chaohu 238000) Xu Xianxiang (Department of Pharmacy, Anhui College of TCM,Anhui Hefei 230038) Jiang Doufa(Fanchang County Hospital of TCM, Anhui Fanchang 241200);Researches on Antithrombotic Effect of Total Saponins of Tribulus[J];Primary Journal of Chinese Materia Medica;2001-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Sun Jianxin;Gu Hong;Wang hui(Department of Science and Research, Second MilitaryMedical University,Shanghai,200433);Effect of ginkgo biloba L extract on energy metabolism of ischemic brain in mice[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1995-06
2 Deng Chang qing,et al.(Research Section for Study of Activating Blood and Removing Stasis 410007);EXPERIMENTAL STUDYI ON MACHENISM OF STRENGTHEN-ING QI AND ACTIVATING BLOOD THERAPY ANTI RE-PERFUSION INJURY OF CEREBRAL ISCHEMIA[J];JOURNAL OF HUNAN COLLEGE OF TRADITIONAL CHINESE MEDICINE;1994-02
3 Chen Jianxiong,et al(Department of Pharmacology,Hengyang Medical College,Hengyang,421001);Edema,Cation and Lipid Peroxide Content after Photochemically Induced Middle Cerebral Artery Occlusion in Rats[J];JOURNAL OF HENGYANG MEDICAL COLLEGE;1996-04
4 Qi Songtao, Zhu Cheng, Lu Yicheng ( Neurosurgical Dept. of Changzheng Hospital, Shanghai 200003) Ye Chunling (Pharmacological Dept. of Jiangxi Medical College, Nanchang 336400);THE PROTECTIVE EFFECTS OF TETRADRINE ON CEREBRAL ISCHEMIA[J];Chinese Pharmacological Bulletin;1992-01
5 ZHANG Ying-Ge, KE Jun (Deft. Pharmacology, Henau Medical University, Zhengzhou 450052);The influence of anisodamine on the cerebral blood flow in uncompletely ischemic rat brains[J];Chinese Pharmacological Bulletin;1992-04
6 QIU Yue; DU Guan-Hua; QU Zhi-Wei;ZHANG Jun-Tian(Department of Pharmacology,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050);Protective effects of ginsenoside on the learning and memory impairment induced by transient cerebral ischemia-reperfusion in mice[J];CHINESE PHARMACOLOGICAL BULLETIN;1995-04
7 Zhu Haibo Fang Wenlong (Department of Pharmacology);Protective Effect of Ginsenoside Re on Acute Cerebral Ischemia/Reperfusion Injury of Rats[J];Journal of Medical Science Yanbian University;1993-01
8 WANG Zhu-Yun, QIU Pei-LunDepartment of Pharmacology, Xi'an Medical University, Xi'an 710061;Protective effect of gypenosides on acute incomplete cerebralischemia in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1992-03
9 GH Du and JT Zhang (Institute of Materia Medica,Peking Union Medical College and Chinese Academy of medical Sciences,Beijing 100050);PROTECTIVE EFFECTS OF SALVIANOLIC ACIDA AGAINST IMPAIRMENT OF MEMORY INDUCED BY CEREBRAL ISCHEMIA-REPERFUSION IN MICE[J];ACTA PHARMACEUTICA SINICA;1995-03
10 JC Dongand LN Xu(Institute of Materia Medica,Chinese Academy of Medical Sciences,peking Union Medical College,Beijing 100050);BENEFICIAL EFFECTS OF ACETYLSALVIANOLIC A ON FOCAL CEREBRAL ISCHEMIC RATS SUBJECTED TO MIDDLE CEREBRAL ARTERY THROMBOSIS[J];ACTA PHARMACEUTICA SINICA;1996-01
【Secondary References】
Chinese Journal Full-text Database 5 Hits
1 QU You-zhi,GAO Guo-dong,ZHAO Yan-ling (Department of Neurosurgery,Tangdu Hospital,The 4th Military Medical University, Shaanxi Xi’an 710038,China);EFFECT OF LIGUSTRAZINE AND ASTRAGUS ON EXPRESSION OF c-jun IN RAT BRAINS AFTER CEREBRAL ISCHEMIA- REPERFUSION INJURY[J];Journal of Anhui Traditional Chinese Medical College;2000-06
2 TAN Bao_xuan, CHEN Chao_feng, CHEN Jie_wen, LI Xiao_ying, WANG Yong (Dept. of Physiology, Guangzhou University of TCM,Guangzhou 510405,China);Effects of the Therapy of Reinforcing Qi and Activating Blood Circulation on Acute Cerebral Ischemia and Its Mechanism[J];JOURNAL OF GUANGZHOU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1999-01
3 Tan Baoxuan; Chen Jiewen; Chen Chaofeng; et al.(Dept. of Physiology, Guangzhou University of TCM, (GuangDong 510407);Protective Effects of the Therapy of Reinforcing Qi and Activating Blood Circulation on Acute Cerebral Hypoxia[J];SHENZHEN JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTEM MEDICIN;1999-06
4 LI Li, et al(Research Center of Biochemistry and Molecular Pharmacology,College of Basic Medicine,Chongqing Medical University);Establishment of mice model with learning and memory deficits induced by cerebral ischemia/reperfusion[J];Journal of Chongqing Medical University;2005-03
5 QU You-zhi GAO Guo-dong ZHAO Yan-ling Department of Neurosurgery,Tangdu Hospital,Fourth Military Medical University,Xi'an(710038);Expression of Fos Protein in Rat Brains after Focal Cerebral Ischemia Followed by Reperfusion and Effects of Ligustrazine and Astragus[J];Chinese Journal of Integrated Traditional and Western Medicine;2002-S1
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Li Donghui Qiu Peilun Li Guangyuan Mu Qiyun (Dept. of Pharmacology, Xian Medical University);Effect of Gypenosides on Myocardial Ischemia/Reperfusion Injury in Rats[J];Basic Medical Sciences and Clinics;1990-01
2 Chen Jue & Xu Hengjun (Department of Pharmacology, Institute of Materia Medica Zbejiang Academy 玣 Medicine, Hangzhoti);EFFECT OF GYNOSTEMMA PENTAPHYLLUM ON THE LIFE SPAN OF FRUIT FLY[J];Chinese Pharmacological Bulletin;1987-06
3 Chang Shuying, Kuang Peigen et al (Chinese PLA General Hospital, Beijing);MEMORY FACILITATION INDUCED BY GYNOSTEMMA PENTAPHYLLUM AND GYPENOSIDE Ⅲ ( GINSENOSIDER b_1 ) IN MICE[J];Chinese Pharmacological Bulletin;1988-06
4 Chen Chao , Fang Dachao ( Dept. of Pharmacology, Tongji Medical University, Wuhan 430030 )Department of Pharmacology,Yichang Medical College,Hubei 443003;EFFECTS OF PALMATINE ON ELECTROPHYSIOLOGICAL CHARACTER IN THE ISOLATED GUINEA PIG PAPILLARY MUSCLES[J];Chinese Pharmacological Bulletin;1991-02
5 Li Lin1, Xing Shantian, Zhou Jinhuang ( Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850);PROTECTIVE EFFECTS OF GYPENOSIDES ON RAT HEPATIC LIPID PEROXIDATION AND MEMBRANE FLUIDITY DAMAGE: IN VITRO STUDIES[J];Chinese Pharmacological Bulletin;1991-05
6 CHU Guo-xiang CHEN Xiu (Dept. Pharmacology,Hunan Medical University,Changsha 410078);Protective effect of ginsenosides on acute cerebral ischemia/reperfusion injury of rats[J];Chinese Journal of Pharmacology and Toxicology;1989-01
7 CHEN Li-Feng,QIU Sai-Hong,LI Qun-Ai,HE Yong-Jian (Hunan Academy of Traditional Chinese Medicine and Materia Medico,Changsha 410006);Comparison between the effcts of gypenosides and ginsenosides on cardiac function and hemodynamics in dogs[J];Chinese Journal of Pharmacology and Toxicology;1990-01
8 WU Ji-Liang,QIU Pei-Lun,LIU Jun-Tian,MU Qi-Yun,XIN Dong-Sheng (Dept Pharmacology,Xian Medical University,Xian 710061);Effects of gypenosides on platelet aggregation release and cAMP level in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1990-01
9 LIAO Duan-Fang, CHEN Xiu Department of Pharmacology, Hunan Medical University, Changsha 410078;A new method to study correlation between endothelium damage and free radicals[J];Chinese Journal of Pharmacology and Toxicology;1991-03
10 Li Ying-Ying, et al Department of Pathophysiology, Kunming Medical College, Kunming;Studies on acute incomplete cerebral ischemic and reperfusion damages in rabbits[J];Chinese Journal of Pathophysiology;1987-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved