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《JOURNAL OF HENGYANG MEDICAL COLLEGE》 1997-04
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Effect of COF on Chromosome Aberration Rate and Micronucleus Rate of Marrow of Mice

Rang Weiqin;Li Dongyang Zhou Shaoqin; et al(Dept. of Preventive Medicine of Heng yang Medical College, Hengyang, 421001 )  
The mutagenicity of cook oll fumes(COF) was detected with chromosome aberration test and micronucleus test in bone marrow cells of mice after exposure to COF. The results showed that COF could induce a significant increase (P0. 05) of chromosome aberration rate at doses of 28, 63, and 100 (mg/m3) respectively compared with negative controls. A close effect relationship clearly existed. COF could induce an increase of mlcronuclei frequencles at various given doses and the correlation coefficient was 0. 88 with chromsome aberration rate and micronucleus rate.The results proved that COF Could induce the increase of chromosome aberration rate and micronuclei frequencies in bone marrow cells of mice.
【Key Words】： COF bone marrow cells chromosome aberration micronuclei
【CateGory Index】： R329.2
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