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Effect of Gypenosides on Mean Arterial Pressure and Nitric Oxide Levels in Rabbits with Endotosin Induced Shock

Tang Chaoke, Sun Ming, Wen Gebo, Hu Bi, Liao Duanfang (Department of Diagnostics of Hengyang Medical College, Hengyang, 421001)  
Aim To investigate the effects of Gypenosides on mean arterial pressure and nitric oxide levels in rabbits with endotoxin indueced shock. Methods Rabbits were randomly divided into three groups, i.e. control, endotoxin (LPS), and endotoxin plus Gypenosides (GPS). The animals were anaethetized with intravenous injection of 20% ethyl urethane. Mean arterial pressare was determined. Nitric oxide levels were determined by the method of colorimetric analysis. Results All the investigated values in control group were not significantly changed during the experiment. The plasma level of nitric oxide in GPS group was lower than that in LPS group but higher than that in control group after administration of Gypenosides. MAP showed significant difference between LPS and GPS groups, and both of them were lower than control group. The investigation demonstrated that Gepenosides prominently improved the mean arterial pressure of the rabbits, and delayed the animal death caused by shock. Conclusion It appeared to the author that the mechanism of the improvement might involve decrease of NO level and the improvement of shock.
【CateGory Index】: R285
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Chinese Journal Full-text Database 1 Hits
1 ZHANG Tao1,YUAN Di-shun2(1.Agricultural Product Quality Institute,Fujian Agriculture and Forestry University,Fuzhou 350002,China;2.Institute of White Tea,Fujian Agriculture and Forestry University,Fuzhou 350002,China);Effective Components of Gynostemma pentaphyllum and Research Advances in Gypenosides[J];Acta Agriculturae Jiangxi;2008-09
Chinese Journal Full-text Database 2 Hits
1 Bin Xiaonong;Tan Min(Hengyang Medical College,Hengyang,Hunan);Effect of Gypenosides on Natural Killer Cells Activity of Spleen in Mice[J];JOURNAL OF HENGYANG MEDICAL COLLEGE;1994-02
2 WANG Zhu-Yun, QIU Pei-LunDepartment of Pharmacology, Xi'an Medical University, Xi'an 710061;Protective effect of gypenosides on acute incomplete cerebralischemia in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1992-03
Chinese Journal Full-text Database 10 Hits
1 LIU Hong, JIN Xi yu, WU Xiong fei (Department of Kidney, Southwest Hospital, the Third Military Medical University, Chongqing 400038, China);Changes of endothelin-1 and nitric oxide after renal ischemia/reperfusion injury[J];Chongqing Medical Journal;2002-04
2 He Ying;Wang Dongwu;Den Zhikuan(Department of Neurology,Xinqiao Hospital,Third Military Medical University,Chongqing,630038)Zhang Wei(Department of Statistics, Third Military Medical University,Chongqing,630038);Changes of intracellular calcium content and cerebral ultrastructures after brainstem ischemia in dogs[J];ACTA ACADEMIAE MEDICINAE MILITARIS TERTIAE;1996-02
3 Wang Xu, Li Genfeng, Yang Zongcheng (Research Institute of Burns, Southwest Hospital, Third Military Medical University, Chongqing, 400038);Preventive effects of collagen solution on acute injury of the gastric mucous membrane in rats[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1998-01
4 Li Jianming;Jin Lijuan; Wang Jinzheng (Department of pathophysiology,First Military Medical University);Role of nitric oxide in the pathogenesis of postburn hypermetabolic multiple organ dysfunction syndromes in rats[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;1997-02
5 ZHENG Lilan,XU Jianqin(College of Veterinary Medicine, China Agricultural University, Beijing, 100094,China);Research Progress on Traditional Chinese Medicine in the Immune Mechanism[J];Progress In Veterinary Medicine;2004-06
6 LIU Hong (Dept.of Pharmacology,Hubei Institute for Nationalities,Enshi 445000);Effects of Ligustrazini on Nitric Oxide,Endothelin and Lipidperoxidation in Experimental Atheroscierotic Rabbits[J];Journal of Hubei Institute For Nationalities Medical Edition;2000-04
7 Yu Juan;Yang Shanzhang(Department of Pathophysiology,Fujian Medical College,Fuzhou,350004);Observation of Effects of Gynostemma Pentaphyllum on Platelet Disaggregation in Human[J];;1995-03
8 Fan Xueliang,et al Department of Pathophysiology,Zunyi Medical College;The Changes of Plasma NO and the Effects of Radix Rheum Officinale and Radix Salvia Miltiorrhizae in Rats with Experimental Acute Pancreatitis[J];JOURNAL OF GUIYANG MEDICAL COLLEGE;1997-03
9 Chen Yan,Chen Juan,Hu Renjun,et al.Pediatric Dept.of Affiliated Hospital of Zunyi Medical College,Zunyi,563003;The change and clinical significance of Nitric Oxide concentration in cerebrospinal fluid of children with epidemic cerebrospinal meningitis[J];Guizhon Medical Journal;2000-08
10 LI Shu-hui,LI Xiao-hui,ZHANG Hai-gang,TANG Yuan,ZHOU Jian-zhi,WANG Xiao-qin,HU Jian (Department of Pharmacology,The Third Military Medical University,Chongqing400038,China);Experimental Study on the Anti-inflammatory Mechanisms of Panax Notoginsengnoside of the Leaves[J];Journal of Heilongjiang Commercial College (Natural Sciences Edition);2002-01
Chinese Journal Full-text Database 10 Hits
1 Wang Yuanjing,Shen Guoming,Wang qinmao (Department of Combination of Chinese and Western Medicin, Anhui College of TCM,Hefei 230038,China);THE PROTECTIVE EFFECTS OF LIGUSTRAZINE ON ACUTE CEREBRAL ISCHEMIA REPERFUSION INJURY IN RATS[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-01
2 Li Feng,Zhang Xiaoming,Zhang Yun,Ye Chuanhui,Cheng Qingli (Department of TCM,Xijing Hospital,Fourth Military Medicial University,PLA,Xi’an 710032,China);EFFECT OF SHENKANG INJECTION ON LEVEL OF ET 1 AND NO SECRETION IN CULTURED GLOMERULAR MESANGIAL CELL[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-02
3 Chen Qianfen;Tian Hecun;Zhang Chenyin;Chu Dekai;Yang Weidong(Department of Pathophysilolgy,Bengbu Medical College,Anhui 233003);Protective effect of gypenosides on global cerebral ischemia-reperfusion injury in rat[J];ACTA ACADEMIAE MEDICINAE BENGBU;1996-06
4 XU Lu DONG Zhi HUANG Yan(Chongqing University of Medical Sciences,Chongqing 400016);The Experimental Research on Hypnogenetic Effects of Gypenosides[J];;2006-04
5 LIN Ru 1,2 ,CAO Yu fang 2,HU Zheng hai 2* (1 College of Life Science,Fujian University of Agriculture and Forestry,Fuzhou 350002,China;2 Institute of Botany,Northwest University,Xian 710069,China);Anatomical structure of vegetative organs and histochemical localization of ginsenosides in Gynostemma pentaphyllum[J];Acta Botanica Boreali-occidentalia Sinica;2002-04
6 SUN Jun, LI Jing-Feng, YAO Xiu-Juan, ZHAO De-Hua Department of Pharmacology, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710033, China;Anisodamine acts on blood pressure and NO synthesis in endotoxic shock rabbits[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-07
7 CHEN De kun (College of Animal Husbandry and Veterinary Science,Northwestern Sci Tech University of Agriculture and Forestry,Yangling,Shaanxi,712100,China);Review of Endotoxin and Signal Molecules of Cell Membrane and Nucleus Involved in Endotoxication[J];Progress In Veterinary Medicine;2002-02
8 WANG Feng long,YIN mei,RIMU D ma (The College of Animal Science and Medicine,Inner Mongolia Agricultural University, Huhhot,Inner Mongolia,010018,China);Induction and the Biological Activity Detection of Tumor Necrosis Factor in Chickens[J];Progress In Veterinary Medicine;2003-05
9 SUN Hai-hong ~(1),MA Tong-suo~(2 ),YU Shan~(1),ZHAO Bao-hua~(1) (1.College of Life Science, Hebei Normal University, Shijiazhuang,Hebei,050016,China; 2.College of Biology Science and Biotechnology, Hebei Economic and Trade University,Shijiazhuang,Hebei,050061,China);Preparation of Inactive Vaccine Against Chicken E.coli[J];Progress In Veterinary Medicine;2005-04
10 LIU Shi-biao~1,LIN Ru~2,HU Zheng-hai~3(1.Institute of Ecology,Jishou University,Jishou,Hunan 416000,China;2.College of Life Science,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China;3.Institute of Botany,Northwest University,Xi′an,Shaanxi 710069,China);Comparison of stem and leaf structures and total gypenosides among 5 species of Gynostemm[J];;2006-05
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Wang Yan1, Ding Hong2, Xiao Geng- Fu1 1.College of Life Sciences, Wuhan University, Wuhan,Hubei,430072, P.R.China 2.College of Pharmacy, Wuhan University, Wuhan,Hubei,430072, P.R.China;Research Advances on Tumor Therapy via Nitric Oxide[J];Chinese Journal of Cancer;2004-04
2 LIU Hong-bai~(1,2), LU Tong-yan~(2), ZHANG Chun-yan~(3), SUN Da-jiang~(2),BAI Xiu-juan~1 (1.Northeast Agriculture University,Harbin 150030,China;2.Heilongjiang River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Harbin 150070,China;3.Heilongjiang Traditional Chinese Medical University,Harbin 150030,China);Effects of the aqueous extract of astragalus root Astragalus membranaceus on immunity and antioxidation in Amur sturgeon (Acipenser schrencki Brandt)[J];Journal of Dalian Fisheries University;2006-03
3 LAI Qing-wu,ZHANG Yi (School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China);Studies on Fermentation Kinetics of Gypenoside[J];Modern Food Science and Technology;2009-10
4 Zhang Tao~1 Zhang Yusong~2 Zhang Shunping~1 Lai Cuixia~1 Li Chunju~1 Yuan Dishun~(1,3) 1 Agricultural Product Quality Institute,Fujian Agriculture & Forestry University,Fuzhou 350002;2 Science and Technology Development Corporation,Fujian Agriculture and Forestry University,Fuzhou 350002; 3 White Tea Research Institute,Fujian Agriculture & Forestry University,Fuzhou 350002;Content Analysis of Gypenosides of Gynostemma pentaphyllum from 10 provinces in China[J];Chinese Journal of Tropical Crops;2008-06
5 GE Min1,LIU Tong2,GUAN Su-dong3,MA Shan-feng3,WU Ying-liang1 (1.School of Pharmay,Shenyang Pharmaceutical University,Shengyang 110016,China;2.Pharmacological Laboratory,Liaoning Institute for Drug Control,Shenyang 110023,China;3.Bengbu Medical College,Bengbu 233030,China);Effects of gypenosides on cardiac function in diabetic cardiomyopathy rats[J];Journal of Shenyang Pharmaceutical University;2007-06
6 Cui Jun,Wang Youqun,Chang Feifei(Pharmacology Institute of China Pharmaceutical Unversity,Nanjing 210009,Jiangsu,China);Study on screening and mechanism of action of Chinese medicine formulas on early diabetic[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2009-15
7 ZENG Yi-li,PAN Jing-xin.(Department of Hemopathology,the Second Hospital Affiliated to Fujian Medical University,Quanzhou 362000,China);The Multiplicitive Roles of Nitric Oxide on Tumor[J];Medical Recapitulate;2009-11
8 LIANG Jing-yu1,WU Yi-ling2,JIA Zhen-hua2,QI Jin-sheng 1(1.Department of Biochemistry,Hebei Medical University,Shijiazhuang 050017,China;2.Yiling Medical Research Institution of Hebei,Shijiazhuang 050035,China);Effect of Tongxinluo on the interaction between COX-2 and iNOS in vascular injury of rats with deficiency of vital energy or qi stagnation[J];Chinese Traditional Patent Medicine;2009-06
9 ZHANG Yi-hua,PENG Si-xunCenter of Drug Discovery,China Pharmaceutical University,Nanjing 210009,China;Advances in the research of nitric oxide-donating drugs[J];Journal of China Pharmaceutical University;2006-05
10 MAO Qing-qiu,HUANG Zhen(Department of pharmacy,Zhejiang University of Traditional Chinese Medicine,Hangzhou 31005,China);Research progress on therapeutic mechanism of depression treated by traditional Chinese medicine[J];China Journal of Chinese Materia Medica;2007-10
China Proceedings of conference Full-text Database 2 Hits
1 Liu Hongbai Zhang Ying (Heilongjiang River Fishery Research Institute,Chinese Academy of Fishery Sciences,Harbin 150070,China);Effects of five kinds of Chinese herbal medicine on nitric oxide concentration in serum of common carp and their remission of nitric oxide toxicity of anthon[A];[C];2003
2 WU Yiling~* LI Yanning QI Jinsheng ~*Yiling Medical Research Institution of Hebei,Shijiazhuang 050035,China;Effect of Tongxinluo on 7 genes expression profile associated with vascular endothelium injure of rats with deficiency of vital energy or qi stagnation[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 8 Hits
1 Li Donghui Qiu Peilun Li Guangyuan Mu Qiyun (Dept. of Pharmacology, Xian Medical University);Effect of Gypenosides on Myocardial Ischemia/Reperfusion Injury in Rats[J];Basic Medical Sciences and Clinics;1990-01
2 Chen Jue & Xu Hengjun (Department of Pharmacology, Institute of Materia Medica Zbejiang Academy 玣 Medicine, Hangzhoti);EFFECT OF GYNOSTEMMA PENTAPHYLLUM ON THE LIFE SPAN OF FRUIT FLY[J];Chinese Pharmacological Bulletin;1987-06
3 Chang Shuying, Kuang Peigen et al (Chinese PLA General Hospital, Beijing);MEMORY FACILITATION INDUCED BY GYNOSTEMMA PENTAPHYLLUM AND GYPENOSIDE Ⅲ ( GINSENOSIDER b_1 ) IN MICE[J];Chinese Pharmacological Bulletin;1988-06
4 QIAN Bo-chu, ZANG Xing-xing, CHEN Jue, XU Heng-jun, LIU Xue-li, YUAN Yu-ying, PENG Xiao-ying(Department of Pharmacology, Institute of Materia Medica, Zhejiang Academy of Medicine, Hangzhou 310007);Influence of gypenosides on immunological function in rodents[J];Chinese Journal of Pharmacology and Toxicology;1986-01
5 CHU Guo-xiang CHEN Xiu (Dept. Pharmacology,Hunan Medical University,Changsha 410078);Protective effect of ginsenosides on acute cerebral ischemia/reperfusion injury of rats[J];Chinese Journal of Pharmacology and Toxicology;1989-01
6 WU Ji-Liang,QIU Pei-Lun,LIU Jun-Tian,MU Qi-Yun,XIN Dong-Sheng (Dept Pharmacology,Xian Medical University,Xian 710061);Effects of gypenosides on platelet aggregation release and cAMP level in rabbits[J];Chinese Journal of Pharmacology and Toxicology;1990-01
7 ZHANG Yong-Xiang, ZHOU Jin-Huang, XING Shan-Tian,YUAN Shu-Lan. RUAN Jin-Xiu Institute of Pharmacology and Toxicology, Beijing 100850;Effects of gypenosides on splenocyte proliferation and relationships with hypothalamic and splenic norepinephrine and plasma corticosterone in rats[J];Chinese Journal of Pharmacology and Toxicology;1992-04
8 Li Ying-Ying, et al Department of Pathophysiology, Kunming Medical College, Kunming;Studies on acute incomplete cerebral ischemic and reperfusion damages in rabbits[J];Chinese Journal of Pathophysiology;1987-02
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