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Effect of Gypenosides on Mean Arterial Pressure and Nitric Oxide Levels in Rabbits with Endotosin Induced Shock

Tang Chaoke, Sun Ming, Wen Gebo, Hu Bi, Liao Duanfang (Department of Diagnostics of Hengyang Medical College, Hengyang, 421001)  
Aim To investigate the effects of Gypenosides on mean arterial pressure and nitric oxide levels in rabbits with endotoxin indueced shock. Methods Rabbits were randomly divided into three groups, i.e. control, endotoxin (LPS), and endotoxin plus Gypenosides (GPS). The animals were anaethetized with intravenous injection of 20% ethyl urethane. Mean arterial pressare was determined. Nitric oxide levels were determined by the method of colorimetric analysis. Results All the investigated values in control group were not significantly changed during the experiment. The plasma level of nitric oxide in GPS group was lower than that in LPS group but higher than that in control group after administration of Gypenosides. MAP showed significant difference between LPS and GPS groups, and both of them were lower than control group. The investigation demonstrated that Gepenosides prominently improved the mean arterial pressure of the rabbits, and delayed the animal death caused by shock. Conclusion It appeared to the author that the mechanism of the improvement might involve decrease of NO level and the improvement of shock.
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