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《Journal of Hengyang Medical College》 2001-02
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Protective Effect of Gypenosides on Ischemic Brain Damage Induced by Photochemistry

TANG Xiao-qing,ZHU Bing-yang,CHEN Jian-xiong,et al (Institute of Pharmacy & Pharmacology,Nanhua University,Hengyang,Hunan 421001,China) [WT5HZ]  
Aim:To study the effects of gypenosides on ischemic brain damage induced by photochemistry in rats. Methods:The rat modle of middle cerebral artery occlusion(MCAO)was induced by photochemistry.The contents of Ca 2+ ,H 2O and MDA,NO level and superoxide dismutase(SOD) activity were measured. Results:After MACO,cerebral ischemia was formed,NO level and SOD activity were decreased,the contents of H 2O,Ca 2+ and MDA were increased.Gyp could reduce the ischemic areas of brain and decrease contents of H 2O,Ca 2+ and MDA.Furthermore,Gyp also increased NO level and SOD activity of brain. Conclusion:Decrease of NO level and Ca-overload were important factors leading to ischemic brain damage.Gyp could protect ischemic brain damage by influencing pathological change of NO and Ca 2+ levels.
【Fund】: 湖南省自然科学基金!资助课题 ;;NO :942 0 933;; 湖南省教委资助!课题 ;;NO :11912 0 6
【CateGory Index】: R743.3
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