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《Journal of Zhejiang University(Sciences Edition)》 2003-06
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Hypogycemic effect of the polysaccharide from Dendrobium moniliforme (L.) Sw

CHEN Yun-long~(1,2), HE Guo-qing~1, ZHANG Ming~2, LI Hui-jun~2(1. College of Biosystem Engineering and Food Science, Zhejiang University, Hangzhou 310029, China; 2. College of Life Sciences, Zhejiang University, Hangzhou 310028, China)  
To observe the hypoglycemic effect of polysaccharides from Dendrobium moniliforme (L.) Sw. (DMP) on experimental diabetic mice and discuss the anti-hyperglycemic mechanism, mice were divided into different groups and each group was given DMP(100 and 200 mg·kg~(-1), ig), glybenclamide(50 mg·kg~(-1),ig), phenformin(50 mg·kg~(-1), ig) or normal saline, respectively. The levels of serum glucose were determined in normal control groups and diabetic mice groups induced by adrenalin(20 mg·kg~(-1), ip) or alloxan(200 mg·kg~(-1), ip). Both doses of DMP(100 and 200 mg·kg~(-1), ig) could remarkably decrease the serum glucose in adrenalin and alloxan induced diabetic mice(p0.01) and increase glucose tolerance. On the other hand, it was found that DMP has no significant influence on the serum glucose level of normal mice. DMP has significant effects of hypoglycemic action in diabetic mice. It is worthy to be utilized to develop medicines for diabetes.
【Fund】: 浙江省自然科学基金资助项目(301560).
【CateGory Index】: R285
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