The Active Oxygen Radical Mechanism and the Biological Effect of Selenium
Xu Huibi Sun Enjie Yang Xiangliang Zou Juan
Based on a series of investigations on various biological effects of Se and the work reported in literature, the active oxygen radical (AOR) mechanism relating to the biological effect of selenium has been found. In a given biological system, Se will scavenge AOR. However, the physiological function goes on normally. But in a high concentration, Se will catalyze the generation of AOR under certain conditions, and toxicity will be manifested. This may well be an explanation about the relation between the biological effect of Se and its concentration described by the Weinberg principle.