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《Journal of Huazhong Agricultural University(Natural Science Edition)》 2006-06
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Effect of CdCl_2 on Sperm Quality and Sex Ratio of Mouse Offspring

YU Rong LONG XiangXIONG Jia-junGENG Li-yingYANG Li-guo(College of Animal Science and Technology,Huazhong Agricultural University,Wuhan 430070,China)  
The effect of CdCl_2 on male mouse reproduction and sex ratio were studied in this paper on the basis ofdosage and processing time.A total of32 male Kunming mice weredivided into 4 groups.Animals in each group were given ahypodermic injection ofCdCl_(2) in dosage of 0,0.5,1,2(mg/kg) every day respectively for five consecutive weeks.Semen quality was then detected.The results showed thatsperm concentration and motility decreased significantly(P0.05),but sperm abnormalityrate elevatedremarkably(P0.05)in semen original from epididymisin a dosage dependence relationship,resulting in a low fertility rate,a small litter size and low body weight of the offspring at birth,but a greater female sex ratio in a dosage dependent relationship when the males were used to mate 64 female mice.In conclusion,cadmium chloride is harmful to the sperm leading to a high ratio of female offspring.
【Fund】: 湖北省自然科学基金项目(2005ABA147);; 武汉市重点攻关项目(20022005132-19)资助
【CateGory Index】: S865.1+30.3
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