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Effects or Phyllanthus Urinarial (PUL) on the Differentiation of Human Hepatocarcinoma Cell Strain Bel-7402

Huang Yuhua, Zhang Jianjun, Yan Xuesheng, Peng Shenan, Wang Boxiang (Affiliated Hospital of Hubei College of TCM Wuhan 430061)  
To study effects of PUL on the differenhation of human hepatocarcinoma cell stain Bel-7402. Methods: the first experiment approach adpted the addition of the rabbits serums, which were from the rab- bits that were drenched with PUL for seven days, to the cell culture medium, it is called as serological phar- macological test; In the second experiment, PUL were added to the cell culture medium directly. Cytobiolog- ical methods were used to study the cell growth, clone forming,the synthesis and secretion of AFP and ACB, the γ-GT activity, the morphosis of the treated Bel-7402 cells. Results: PUL and its serums could inhibit cell growth and clone forming, and decrease the synthesis and secretion of AFP, and inhibit γ-GT activity, and add the synthesis and secretion of ALB, there were concentration dependence relationship and time depen- dence relationship, to some extent, and induced hepatocarcinoma cells to differentiate toward normal style. Conclusion: PUL could induce human hepatocarcinoma cell strain Bel-7402 to differentiate toward normal style and prevent the occurrence of PHC
【Fund】: 湖北省教委资助
【CateGory Index】: R273
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