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《Journal of Hubei College of Traditional Chinese Medicine》 2004-01
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Effects of Qijian Xiaoying Decoction on TNF, IL-6 of Autoimmune Thyroiditis in Mice

Hua Chuan, Chen Ruquan Nanjing University of Traditional Chinese Medicine, Nanjing 210029 Hubei College of Traditional Chinese Medicine, Wuhan 430061  
Observe the effects and mechanism of Qijian Xiaoying decoction to EAT in murine on autoantibodies, cytokines induced by mice peritoneal macrophage and pathology. Method: Injection of hTg and CFA can induce EAT. Survey autoantibody levels with PHA. Observe the pathology changes of thyroid tissue of murine with HE colouration. Gather murine peritoneal macrophage to investigate the levels of TNF and IL-6 with RIA. Results; Qijian Xiaoying decoction can suppress obviously autoantibody levels and alleviate lymphocyte soakage of murine thyroid tissue. TNF and IL-6 in model group were higher than that in control group (P 0. 01). The data of TNF in SQJ and TT group were markedly decreased ( P 0. 01). The levels of IL-6 in BQJ and SQJ group were significantly lower than that of model group ( P 0. 01 ). Conclusion : Qijian Xiaoying decoction can adjust autoimmune disorder and the releasing of cytokines in Hashimoto's Thyroiditis, which have distinctness curative effect on EAT.
【CateGory Index】: R285.5
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