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《Journal of Hubei University of Chinese Medicine》 2009-04
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Influences of Medicine and Catgut Embedding In Acupoints On Matrix Metalloproteinase-9 In Cortex Tissues of Rats With Focal Cerebral Ischemia Reperfusion Injury

ZHOU Hong-juan,KONG Li-hong,YE Yu-wan,CUI Chang-xiang(Hubei University of Chinese Medicine,Wuhan 430061,China)  
Objective To observe the effects of embedding medicine and catgut in acupoints on the expression and contents of Matrix Metalloproteinase-9(MMP-9) in cortex tissues of rats with focal cerebral ischemia reperfusion injury,and discuss the protective mechanisms of embedding medicine and catgut in Acupoints against the focal cerebral ischemia reperfusion injury.Methods 42 SD rats were randomly divided into normal group,model groups(subgroups: 1d,3d,5d),Acupoints embedding groups(subgroups: 1d,3d,5d).The modified method of suture embolism was used to produce middle cerebral artery occlusion(MCAO) and reperfusion models.The collagen and Tetramethylpyrazine contained sustained release preparation was embedded into"Baihui"(GV 20) and"Dazhui"(GV 14) Acupoints for the Acupoints Embedding groups.Western blotting was used to determine the expression and content of MMP-9 in ischemic cortex tissues.Results The contents of MMP-9 in cortex tissues of model groups were significantly higher than that of normal group,which had few expression of MMP-9(P0.01).Comparisons between Acupoints Embedding groups and model groups at the same time phases showed significant difference(P0.01),and showed an inclination to normalize the MMP-9 content with the time.Conclusion The method of embedding medicine and catgut in acupoints could obviously down-regulate the expression of MMP-9 in cortex tissues of rats with focal cerebral ischemia reperfusion injury for cerebral protection via reducing cerebral microvascular basement membrane degradation to ensure the integrity of microvessels and attenuate cerebral ischemia reperfusion injury.
【Fund】: 国家中医药管理局基金资助 [06-07JP27]
【CateGory Index】: R245
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